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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
Authors:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ];  Wu, JZ (Wu, Jianzhong)[ 3 ];  Zou, XL (Zou, Xiaoli)[ 3 ];  Liu, Z (Liu, Zheng)[ 4 ];  Yang, XJ (Yang, Xiaojun)[ 4 ];  Wu, CH (Wu, Chunhui)[ 4 ];  Shi, J (Shi, Jing)[ 4 ];  Li, JF (Li, Jianfeng)[ 1 ];  Suo, J (Suo, Jin)[ 1 ];  Wang, Y (Wang, Yu)[ 1 ];  Zhang, RX (Zhang, Rongxia)[ 1 ];  Xu, ZJ (Xu, Zhijian)[ 1 ];  Gong, XD (Gong, Xudong)[ 1,5 ];  He, Y (He, Yang)[ 1 ];  Zhu, WL (Zhu, Weiliang)[ 1,2 ];  Aisa, HA (Aisa, Haji Akber)[ 5 ];  Jiang, HL (Jiang, Hualiang)[ 1,2 ];  Xu, YC (Xu, Yechun)[ 1,2 ];  Shen, JS (Shen, Jingshan)[ 1,2
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A Facile Epoxide Aminolysis Promoted by (t-BuO)(2)Mg and Its Application to the Synthesis of Efinaconazole 期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2018, 卷号: 22, 期号: 5, 页码: 625-632
Authors:  Zhu, FQ (Zhu, Fuqiang);  Xie, YC (Xie, Yuanchao);  Zhang, J (Zhang, Jian);  Tian, GH (Tian, Guanghui);  Qin, HJ (Qin, Hongjian);  Yang, XJ (Yang, Xiaojun);  Hu, TW (Hu, Tianwen);  He, Y (He, Yang);  Aisa, HA (Aisa, Haji A.);  Shen, JS (Shen, Jingshan)
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Identification, synthesis, and control of efinaconazole impurities 期刊论文
PHARMAZIE, 2018, 卷号: 73, 期号: 8, 页码: 438-441
Authors:  Zhu, FQ (Zhu, Fuqiang)[ 1,2 ];  Zhang, J (Zhang, Jian)[ 3 ];  Xiamuxi, H (Xiamuxi, Hainimu)[ 1,2 ];  Chen, WM (Chen, Weiming)[ 1,2 ];  Hu, TW (Hu, Tianwen)[ 3 ];  Yang, XJ (Yang, Xiaojun)[ 3 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Ni, RY (Ni, Runyan)[ 3 ];  Li, J (Li, Jian)[ 3 ];  Suo, J (Suo, Jin)[ 4 ];  Xie, YC (Xie, Yuanchao)[ 4 ];  Shen, JS (Shen, Jingshan)[ 4 ];  Aisa, HA (Aisa, Haji A.)[ 1 ];  He, Y (He, Yang)[ 4 ]
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含苯并噻二唑结构单元的金属有机骨架在可见光催化需氧氧化反应中的应用 期刊论文
化学学报, 2017, 卷号: 75, 期号: 1, 页码: 80-85
Authors:  张文强;  李秋艳;  杨馨雨;  马征;  王欢欢;  王晓军
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可见光催化  金属有机骨架  苯并噻二唑  需氧氧化  非均相催化  
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
Authors:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen;  Chen Tiantian;  Yang Xiaojun;  Jiang Xiangrui;  Shen Jingshan;  Jiang Hualiang;  Aisa Haji Akber;  Xu Yechun;  Li Jianfeng;  Aisa, HA
Adobe PDF(2158Kb)  |  Favorite  |  View/Download:184/1  |  Submit date:2013/11/07
Pde5 Inhibitors  5-bromopyrimidin-4(3h)-ones  
离体培养条件下伊犁贝母四倍体诱导及筛选 期刊论文
时珍国医国药, 2008, 卷号: 19, 期号: 12, 页码: 2849-2851
Authors:  刘传军;  王晓军;  郝秀英;  李晓瑾;  赵民安;  张蜀敏;  曹玉锦;  阳立恒
Adobe PDF(246Kb)  |  Favorite  |  View/Download:176/10  |  Submit date:2012/11/29
伊犁贝母  四倍体  秋水仙素  
甜菜遗传转化及PCR检测 期刊论文
中国甜菜糖业, 2008, 期号: 1, 页码: 41260
Authors:  段肖霞;  郝秀英;  刘传军;  曹玉锦;  欧阳立恒;  王晓军;  赵民安;  王燕飞;  石玉瑚
Adobe PDF(721Kb)  |  Favorite  |  View/Download:146/7  |  Submit date:2012/11/29
甜菜  遗传转化  Pcr  
新疆雪莲多倍体的诱导初探 期刊论文
西北农业学报, 2008, 卷号: 17, 期号: 1, 页码: 216-220
Authors:  张蜀敏;  王晓军;  郝秀英;  徐琴;  陈阳;  刘传军;  曹玉锦;  欧阳立恒
Adobe PDF(635Kb)  |  Favorite  |  View/Download:255/10  |  Submit date:2012/11/29
秋水仙素  新疆雪莲  多倍体  
新疆雪莲组培苗的染色体观察 期刊论文
安徽农业科学, 2008, 卷号: 36, 期号: 3, 页码: 971-972,987
Authors:  张蜀敏;  王晓军;  陈阳
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新疆雪莲  染色体  激素  
甜菜组织培养过程中同工酶及可溶性蛋白质的变化 期刊论文
中国甜菜糖业, 2007, 期号: 4, 页码: 41165
Authors:  段肖霞;  郝秀英;  刘传军;  曹玉锦;  欧阳立恒;  王晓军;  赵民安;  王燕飞;  石玉瑚
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甜菜遗传转化  过氧化物酶  酯酶  可溶性蛋白  聚丙烯酰胺凝胶电泳