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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
Authors:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ];  Wu, JZ (Wu, Jianzhong)[ 3 ];  Zou, XL (Zou, Xiaoli)[ 3 ];  Liu, Z (Liu, Zheng)[ 4 ];  Yang, XJ (Yang, Xiaojun)[ 4 ];  Wu, CH (Wu, Chunhui)[ 4 ];  Shi, J (Shi, Jing)[ 4 ];  Li, JF (Li, Jianfeng)[ 1 ];  Suo, J (Suo, Jin)[ 1 ];  Wang, Y (Wang, Yu)[ 1 ];  Zhang, RX (Zhang, Rongxia)[ 1 ];  Xu, ZJ (Xu, Zhijian)[ 1 ];  Gong, XD (Gong, Xudong)[ 1,5 ];  He, Y (He, Yang)[ 1 ];  Zhu, WL (Zhu, Weiliang)[ 1,2 ];  Aisa, HA (Aisa, Haji Akber)[ 5 ];  Jiang, HL (Jiang, Hualiang)[ 1,2 ];  Xu, YC (Xu, Yechun)[ 1,2 ];  Shen, JS (Shen, Jingshan)[ 1,2
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Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4904-4916
Authors:  Xiamuxi, H (Xiamuxi, Hainimu);  Wang, Z (Wang, Zhen);  Li, JF (Li, Jianfeng);  Wang, Y (Wang, Yu);  Wu, CH (Wu, Chunhui);  Yang, FP (Yang, Feipu);  Jiang, XR (Jiang, Xiangrui);  Liu, YJ (Liu, Yongjian);  Zhao, QJ (Zhao, Qingjie);  Chen, WM (Chen, Weiming)[ 1 ];  Zhang, J (Zhang, Jian)[ 4 ];  Xie, YC (Xie, Yuanchao);  Hud, TW (Hud, Tianwen);  Xu, MS (Xu, Mingshuo);  Guo, S (Guo, Shuang);  Aisa, HA (Aisa, Haji Akber);  He, Y (He, Yang);  Shen, JS (Shen, Jingshan);  Aisa, HA
Adobe PDF(4567Kb)  |  Favorite  |  View/Download:22/0  |  Submit date:2017/10/31
Dopamine  Serotonin  Multireceptor  Atypical Antipsychotic  5-ht1a  
Ursolic Acid Induces Apoptosis Through Mitochondrial Intrinsic Pathway and Suppression of ERK1/2 MAPK in HeLa Cells 期刊论文
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 卷号: 125, 期号: 2, 页码: 202-210
Authors:  Li, Yanhong;  Lu, Xueying;  Qi, Hongxue;  Li, Xiaobo;  Xiao, Xiangwen;  Gao, Jianfeng
Adobe PDF(733Kb)  |  Favorite  |  View/Download:145/1  |  Submit date:2014/11/11
Ursolic Acid  Apoptosis  Hela Cell  Mitogen-activated Protein Kinase (Mapk)  Dual-specific Phosphatase (Dusp)  
熊果酸对H22荷瘤小鼠抗肿瘤及免疫调节作用 期刊论文
实验动物科学, 2013, 卷号: 30, 期号: 5, 页码: 1-5,14
Authors:  李艳红;  李晓波;  陆雪莹;  高剑峰;  肖向文
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熊果酸  小鼠肝癌h22细胞  抑瘤率  免疫调节  Ursolic Acid  HepatoCellular Carcinoma Cell Line Of Mice (H22)  Inhibiting Tumor Rate  Immune Regulation  
熊果酸增强小鼠肝癌细胞疫苗免疫原性的作用 期刊论文
中国生物工程杂志, 2013, 卷号: 33, 期号: 10, 页码: 28-35
Authors:  李艳红;  李晓波;  陆雪莹;  高剑峰;  肖向文
Adobe PDF(625Kb)  |  Favorite  |  View/Download:388/0  |  Submit date:2014/11/11
熊果酸  佐剂  小鼠h22肝癌疫苗  Ursolic Acid  Immunoadjuvant  H22 Hepatocarcinoma Cells Vaccine  
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
Authors:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen;  Chen Tiantian;  Yang Xiaojun;  Jiang Xiangrui;  Shen Jingshan;  Jiang Hualiang;  Aisa Haji Akber;  Xu Yechun;  Li Jianfeng;  Aisa, HA
Adobe PDF(2158Kb)  |  Favorite  |  View/Download:184/1  |  Submit date:2013/11/07
Pde5 Inhibitors  5-bromopyrimidin-4(3h)-ones  
抗辐射加固封装国产存储器的电子辐照试验 期刊论文
信息与电子工程, 2010, 期号: 1, 页码: 87-90
Authors:  卫宁;  王剑峰;  杜婕;  周聪莉;  郭旗;  文林
Adobe PDF(1771Kb)  |  Favorite  |  View/Download:181/12  |  Submit date:2012/11/29
抗辐射封装  屏蔽  存储器芯片  电子辐照试验  
抗辐射加固封装国产存储器电子辐照试验研究 会议论文
, 沈阳, 2009
Authors:  卫宁;  王剑峰;  杜婕;  周聪莉;  郭旗;  文林
Adobe PDF(593Kb)  |  Favorite  |  View/Download:190/1  |  Submit date:2013/04/09
抗辐射封装  电离辐射  电子辐照  国产存储器