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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
Authors:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ];  Wu, JZ (Wu, Jianzhong)[ 3 ];  Zou, XL (Zou, Xiaoli)[ 3 ];  Liu, Z (Liu, Zheng)[ 4 ];  Yang, XJ (Yang, Xiaojun)[ 4 ];  Wu, CH (Wu, Chunhui)[ 4 ];  Shi, J (Shi, Jing)[ 4 ];  Li, JF (Li, Jianfeng)[ 1 ];  Suo, J (Suo, Jin)[ 1 ];  Wang, Y (Wang, Yu)[ 1 ];  Zhang, RX (Zhang, Rongxia)[ 1 ];  Xu, ZJ (Xu, Zhijian)[ 1 ];  Gong, XD (Gong, Xudong)[ 1,5 ];  He, Y (He, Yang)[ 1 ];  Zhu, WL (Zhu, Weiliang)[ 1,2 ];  Aisa, HA (Aisa, Haji Akber)[ 5 ];  Jiang, HL (Jiang, Hualiang)[ 1,2 ];  Xu, YC (Xu, Yechun)[ 1,2 ];  Shen, JS (Shen, Jingshan)[ 1,2
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Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 17, 页码: 4904-4916
Authors:  Xiamuxi, H (Xiamuxi, Hainimu);  Wang, Z (Wang, Zhen);  Li, JF (Li, Jianfeng);  Wang, Y (Wang, Yu);  Wu, CH (Wu, Chunhui);  Yang, FP (Yang, Feipu);  Jiang, XR (Jiang, Xiangrui);  Liu, YJ (Liu, Yongjian);  Zhao, QJ (Zhao, Qingjie);  Chen, WM (Chen, Weiming)[ 1 ];  Zhang, J (Zhang, Jian)[ 4 ];  Xie, YC (Xie, Yuanchao);  Hud, TW (Hud, Tianwen);  Xu, MS (Xu, Mingshuo);  Guo, S (Guo, Shuang);  Aisa, HA (Aisa, Haji Akber);  He, Y (He, Yang);  Shen, JS (Shen, Jingshan);  Aisa, HA
Adobe PDF(4567Kb)  |  Favorite  |  View/Download:21/0  |  Submit date:2017/10/31
Dopamine  Serotonin  Multireceptor  Atypical Antipsychotic  5-ht1a  
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
Authors:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen;  Chen Tiantian;  Yang Xiaojun;  Jiang Xiangrui;  Shen Jingshan;  Jiang Hualiang;  Aisa Haji Akber;  Xu Yechun;  Li Jianfeng;  Aisa, HA
Adobe PDF(2158Kb)  |  Favorite  |  View/Download:184/1  |  Submit date:2013/11/07
Pde5 Inhibitors  5-bromopyrimidin-4(3h)-ones