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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
Authors:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ];  Wu, JZ (Wu, Jianzhong)[ 3 ];  Zou, XL (Zou, Xiaoli)[ 3 ];  Liu, Z (Liu, Zheng)[ 4 ];  Yang, XJ (Yang, Xiaojun)[ 4 ];  Wu, CH (Wu, Chunhui)[ 4 ];  Shi, J (Shi, Jing)[ 4 ];  Li, JF (Li, Jianfeng)[ 1 ];  Suo, J (Suo, Jin)[ 1 ];  Wang, Y (Wang, Yu)[ 1 ];  Zhang, RX (Zhang, Rongxia)[ 1 ];  Xu, ZJ (Xu, Zhijian)[ 1 ];  Gong, XD (Gong, Xudong)[ 1,5 ];  He, Y (He, Yang)[ 1 ];  Zhu, WL (Zhu, Weiliang)[ 1,2 ];  Aisa, HA (Aisa, Haji Akber)[ 5 ];  Jiang, HL (Jiang, Hualiang)[ 1,2 ];  Xu, YC (Xu, Yechun)[ 1,2 ];  Shen, JS (Shen, Jingshan)[ 1,2
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三种维药经典药材生物碱类成分及其生物活性研究 学位论文
, 北京: 中国科学院大学, 2017
Authors:  陈其宾
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阿纳其根  天山堇菜  瘤果黑种草籽  生物碱  生物合成途径  
嘧啶酮类5型膦酸二酯酶抑制剂的设计、合成及生物活性评价和2-脱氧-2-氟-2-碳-甲基-D-核糖-γ-内酯类衍生物的合成研究 学位论文
, 北京: 中国科学院大学, 2013
Authors:  公绪栋
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Pde5抑制剂  嘧啶酮类衍生物  Ed  Hcv  (2r)-3  5-二-o-苯甲酰-2-脱氧-2-氟-2-碳-甲基-d-核糖-γ-内酯  (2r)-3  5-二-o-苄基-2-脱氧-2-氟-2-碳-甲基-d-核糖-γ-内酯  
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
Authors:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen;  Chen Tiantian;  Yang Xiaojun;  Jiang Xiangrui;  Shen Jingshan;  Jiang Hualiang;  Aisa Haji Akber;  Xu Yechun;  Li Jianfeng;  Aisa, HA
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Pde5 Inhibitors  5-bromopyrimidin-4(3h)-ones