XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Jatrophane Diterpenoids from Euphorbia glomerulans
Hasan, A (Hasan, Aobulikasimu)[ 1,2,3 ]; Liu, GY (Liu, Ge-Yu)[ 1,2 ]; Hu, R (Hu, Rui)[ 1,2,3 ]; Aisa, HA (Aisa, H. A.)[ 1,2 ]
2019
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume82Issue:4Pages:724-734
Abstract

In a phytochemical investigation of the whole plant of Euphorbia glomerulans, 17 new (1-17) and five known jatrophane diterpenoids (18-22) were identified. The X-ray crystallographic data of compounds 1, 4, and 21 permitted the definition of the absolute configurations of these compounds. The cytotoxicity and multidrug resistance reversal activities of the 17 new compounds were evaluated on multidrug-resistant MCF-7/ADR cells overexpressing P-glycoprotein. Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds 11 (IC50 value of 5.0 +/- 0.8 mu M) and 12 (IC50 value of 5.2 +/- 2.0 mu M) possessed MDR reversal activities that were as good as that of verapamil (IC50 value of 4.7 +/- 0.6 mu M).

DOI10.1021/acs.jnatprod.8b00507
Indexed BySCI
WOS IDWOS:000466442100005
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5774
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, H. A.)[ 1,2 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Hasan, A ,Liu, GY ,Hu, R ,et al. Jatrophane Diterpenoids from Euphorbia glomerulans[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(4):724-734.
APA Hasan, A ,Liu, GY ,Hu, R ,&Aisa, HA .(2019).Jatrophane Diterpenoids from Euphorbia glomerulans.JOURNAL OF NATURAL PRODUCTS,82(4),724-734.
MLA Hasan, A ,et al."Jatrophane Diterpenoids from Euphorbia glomerulans".JOURNAL OF NATURAL PRODUCTS 82.4(2019):724-734.
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