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Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode
Huang, XY (Huang, Xin-Yi)[ 1,2 ]; Zhang, X (Zhang, Xia)[ 1,2 ]; Pei, D (Pei, Dong)[ 1,2 ]; Liu, JF (Liu, Jian-Fei)[ 1,2 ]; Gong, Y (Gong, Yuan)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 3,4 ]; Di, DL (Di, Duo-Long)[ 1,2 ]
2019
Source PublicationJOURNAL OF SEPARATION SCIENCE
ISSN1615-9306
Volume42Issue:11Pages:2080-2088
Abstract

In this work, a continuous high-speed countercurrent chromatography method has been developed on the basis of elution-extrusion mode and this method was successfully applied to the separation of maslinic and oleanolic acid from the extract of olive pulp. In the process of ` elution', the sample solution was continuously loaded into the column and the maslinic acid was steadily eluted out in this step while highly retained oleanlic acid always stayed in the column. In the process of ` extrusion', the oleanlic acid was pushed out of the column with the stationary phase. In this way, we achieved a large sample loading. A total of 120 mL sample solution (about 89.55% of the column volume) which contains 600 mg olive pulp extract was pumped in the apparatus by a constant-flow pump and the maslinic and oleanolic acids were largely separated within 120 min. Both of these two compounds presented high yields and high purities (271.6 mg for maslinic acid with 86.7% and 83.9 mg oleanolic acids with 83.4%).

Keywordcontinuous separation elution-extrusion mode high speed countercurrent chromatography maslinic acid oleanolic acid
DOI10.1002/jssc.201900112
Indexed BySCI
WOS IDWOS:000470023400014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5755
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)[ 3,4 ]
Affiliation1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China
Recommended Citation
GB/T 7714
Huang, XY ,Zhang, X ,Pei, D ,et al. Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode[J]. JOURNAL OF SEPARATION SCIENCE,2019,42(11):2080-2088.
APA Huang, XY .,Zhang, X .,Pei, D .,Liu, JF .,Gong, Y .,...&Di, DL .(2019).Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode.JOURNAL OF SEPARATION SCIENCE,42(11),2080-2088.
MLA Huang, XY ,et al."Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode".JOURNAL OF SEPARATION SCIENCE 42.11(2019):2080-2088.
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