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Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers
Feng, X (Feng, Xin)[ 1,2 ]; Li, JL (Li, Jialiang)[ 2,3 ]; Li, H (Li, Han)[ 2,3 ]; Chen, H (Chen, Hang)[ 1,2 ]; Li, F (Li, Fei)[ 2,3 ]; Liu, QW (Liu, Quewang)[ 1,2 ]; You, ZH (You, Zhu-Hong)[ 4 ]; Zhou, FF (Zhou, Fengfeng)[ 1,2,3 ]
2019
Source PublicationFRONTIERS IN GENETICS
ISSN1664-8021
Volume10Issue:3Pages:1-13
Abstract

Patients at different ages have different rates of cell development and metabolisms. As a result, age should be an essential part of how a disease diagnosis model is trained and optimized. Unfortunately, most of the existing studies have not taken age into account. This study demonstrated that disease diagnosis models could be improved by merely applying individual models for patients of different age groups. Both transcriptomes and methylomes of the TCGA breast cancer dataset (TCGA-BRCA) were utilized for the analysis procedure of feature selection and classification. Our experimental data strongly suggested that disease diagnosis modeling should integrate patient age into the whole experimental design.

Keywordage feature selection TriVote BRCA classification transcriptome methylome
DOI10.3389/fgene.2019.00212
Indexed BySCI
WOS IDWOS:000462596600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5707
Collection多语种信息技术研究室
Affiliation1.Jilin Univ, Coll Comp Sci & Technol, BioKnow Hlth Informat Lab, Changchun, Jilin, Peoples R China
2.Jilin Univ, Minist Educ, Key Lab Symbol Computat & Knowledge Engn, Changchun, Jilin, Peoples R China
3.Jilin Univ, Coll Software, BioKnow Hlth Informat Lab, Changchun, Jilin, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China
Recommended Citation
GB/T 7714
Feng, X ,Li, JL ,Li, H ,et al. Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers[J]. FRONTIERS IN GENETICS,2019,10(3):1-13.
APA Feng, X .,Li, JL .,Li, H .,Chen, H .,Li, F .,...&Zhou, FF .(2019).Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers.FRONTIERS IN GENETICS,10(3),1-13.
MLA Feng, X ,et al."Age Is Important for the Early-Stage Detection of Breast Cancer on Both Transcriptomic and Methylomic Biomarkers".FRONTIERS IN GENETICS 10.3(2019):1-13.
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