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Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines
Nasrullaev, A (Nasrullaev, Azizbek)[ 1,2 ]; Bozorov, K (Bozorov, Khurshed)[ 1,2 ]; Bobakulov, K (Bobakulov, Khayrulla)[ 1,2 ]; Zhao, JY (Zhao, Jiangyu)[ 1 ]; Nie, LF (Nie, Li Fei)[ 1 ]; Turgunov, KK (Turgunov, Kambarali K.)[ 2 ]; Elmuradov, B (Elmuradov, Burkhon)[ 2 ]; Aisa, HA (Aisa, Haji A.)[ 1 ]
2019
Source PublicationRESEARCH ON CHEMICAL INTERMEDIATES
ISSN0922-6168
Volume45Issue:4Pages:2287-2300
Abstract

A series of novel substituted hydrazone-bearing (unsymmetrical azines, RR1C=N-N=CR2R3) tricyclic quinazoline derivatives are reported. All novel compounds were characterized by H-1, C-13 nuclear magnetic resonance (NMR), and Fourier-transform infrared (FT-IR) analyses. An important intermediate (E/Z)-hydrazono-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline (8) was synthesized from tricyclic quinazoline-4-thione 7 using 80% of hydrazine hydrate. In addition, the antimicrobial activity of all synthesized novel compounds against three types of pathogenic microorganism was tested, revealing that some compounds showed satisfactory good activity and could serve as lead compounds for further drug discovery and development.

KeywordQuinazoline Quinazoline-thione Hydrazone Thioamide Antimicrobial activity
DOI10.1007/s11164-018-03731-x
Indexed BySCI
WOS IDWOS:000461305200032
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5705
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji A.)[ 1 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, 40-1 South Beijing Rd, Urumqi 830011, Peoples R China
2.Acad Sci Uzbek, Inst Chem Plant Subst, Mirzo Ulugbek Str 77, Tashkent 100170, Uzbekistan
Recommended Citation
GB/T 7714
Nasrullaev, A ,Bozorov, K ,Bobakulov, K ,et al. Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2019,45(4):2287-2300.
APA Nasrullaev, A .,Bozorov, K .,Bobakulov, K .,Zhao, JY .,Nie, LF .,...&Aisa, HA .(2019).Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines.RESEARCH ON CHEMICAL INTERMEDIATES,45(4),2287-2300.
MLA Nasrullaev, A ,et al."Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines".RESEARCH ON CHEMICAL INTERMEDIATES 45.4(2019):2287-2300.
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