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Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells
Lan, JZ (Lan, Jinze)[ 1,2 ]; Wu, XX (Wu, Xiaoxia)[ 1 ]; Luo, L (Luo, Liang)[ 1 ]; Liu, J (Liu, Jing)[ 1 ]; Yang, LY (Yang, Lingyan)[ 1 ]; Wang, F (Wang, Fu)[ 1 ]
2019
Source PublicationTALANTA
ISSN0039-9140
Volume197Issue:5Pages:86-91
Abstract

Anterior gradient protein 2 homolog (AGR) is a potential tumor biomarker and plays an important role in tissue development and regeneration. The intracellular detection of AGR is rarely reported. By conjugating the AGR aptamer with a cytosine base sequence as Ag cluster template, a highly fluorescent probe (MA@AgNCs) was synthesized for targeting intracellular AGR. The MA@AgNCs display a maximum fluorescence peak at 565 nm, and possess an excellent quantum yield (QY = 87.43 parts per thousand), small size, great biocompatibility, low toxicity, and good stability. Moreover, the as synthesized MA@AgNCs show high specificity on recognizing breast cancer cells.

KeywordSilver nanoclusters Anterior gradient-2 antigen Aptamer Bio-probe Cell imaging
DOI10.1016/j.talanta.2018.12.089
Indexed BySCI
WOS IDWOS:000460710200011
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5702
Collection环境科学与技术研究室
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Lab Environm Sci & Technol, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lan, JZ ,Wu, XX ,Luo, L ,et al. Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells[J]. TALANTA,2019,197(5):86-91.
APA Lan, JZ ,Wu, XX ,Luo, L ,Liu, J ,Yang, LY ,&Wang, F .(2019).Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells.TALANTA,197(5),86-91.
MLA Lan, JZ ,et al."Fluorescent Ag clusters conjugated with anterior gradient-2 antigen aptamer for specific detection of cancer cells".TALANTA 197.5(2019):86-91.
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