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Cost-effective imprinting to minimize consumption of template in room-temperature ionic liquid for fast purification of chlorogenic acid from the extract of E. ulmoides leaves
Sun, YK (Sun, Ya Kun)[ 1,2,3 ]; Sun, GY (Sun, Guang-Ying)[ 1,2 ]; Jia, M (Jia, Man)[ 1,2,3 ]; Yang, J (Yang, Jian)[ 1,2,3 ]; Liu, ZS (Liu, Zhao-Sheng)[ 1,2 ]; Huang, YP (Huang, Yan-Ping)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ]
2019
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume411Issue:6Pages:1261-1271
Abstract

One of the main challenges in large-scale applications of molecularly imprinted polymers (MIPs) is the significant amount of template needed in polymer preparation. A new strategy based on room-temperature ionic liquids (RTILs) was suggested to solve this problem by reducing the amount of template in the polymerization recipe. The MIP was synthesized with a mixture of dimethyl sulfoxide and RTIL (1-butyl-3-methylimidazolium tetrafluoroborate) as porogen, in which chlorogenic acid (CGA) was used as template, 4-vinylpyridine (4-VP) as functional monomer, and ethylene glycol dimethacrylate (EDMA) as cross-linker. The influence of polymerization variables, including CGA concentrations, and the ratio of 4-VP to EDMA on imprinting effect were investigated comprehensively. Moreover, the properties involving the column permeability, the number of binding sites, and the polymer morphology of the CGA-MIP monoliths were studied thoroughly. The MIP monolith had an excellent column permeability (1.53x10(-13)m(2)) and allowed an ultra-fast on-line SPE, which dramatically shortens the separation time (<10min) and improves the separation efficiency. At high flow velocity (5.0mLmin(-1)), 50L of the extract from Eucommia ulmoides leaves can be loaded directly on the CGA-MIP monoliths and CGA with high purity can be obtained with a recovery of 89.010.05%. As a conclusion, the resulting RTIL-induced approach of preparing MIP may be an effective tool in fabricating MIP in a low-cost way.

KeywordMolecularly imprinted polymer Chlorogenic acid Monolith On-line solid-phase extraction Room-temperature ionic liquid
DOI10.1007/s00216-018-1559-8
Indexed BySCI
WOS IDWOS:000458358400014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5691
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)[ 1,2 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Sun, YK ,Sun, GY ,Jia, M ,et al. Cost-effective imprinting to minimize consumption of template in room-temperature ionic liquid for fast purification of chlorogenic acid from the extract of E. ulmoides leaves[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2019,411(6):1261-1271.
APA Sun, YK .,Sun, GY .,Jia, M .,Yang, J .,Liu, ZS .,...&Aisa, HA .(2019).Cost-effective imprinting to minimize consumption of template in room-temperature ionic liquid for fast purification of chlorogenic acid from the extract of E. ulmoides leaves.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,411(6),1261-1271.
MLA Sun, YK ,et al."Cost-effective imprinting to minimize consumption of template in room-temperature ionic liquid for fast purification of chlorogenic acid from the extract of E. ulmoides leaves".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 411.6(2019):1261-1271.
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