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Photothermally controlled drug release system with high dose loading for synergistic chemo-photothermal therapy of multidrug resistance cancer
Wu, XX (Wu, Xiaoxia)[ 1,2 ]; Liu, J (Liu, Jing)[ 1 ]; Yang, LY (Yang, Lingyan)[ 1 ]; Wang, F (Wang, Fu)[ 1,3 ]
2019
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume175Issue:3Pages:239-247
Abstract

Chemotherapy is an important first-line strategy for tumor therapy in cancer treatment, but multidrug resistance (MDR) is a major problem that reduces the efficacy of chemotherapeutics. Herein, we report a novel photothermally controlled intelligent drug release system (AuNP@mSiO(2)-DOX-FA) with a large amount of drugs loading for synergistic chemo-photothermal therapy of MDR in breast cancer. The nanoplatform utilized gold nanoparticles as a hyperthermia core, and large-mesoporous silica as a shell for doxorubicin (DOX) loading. Benefiting from the thick layer and large pore size, the encapsulation and loading efficiency were as high as 97.7% and 8.84%, respectively. Furthermore, under the trigger of 808 nm near infrared (NIR) light, the released DOX increased significantly at pH 5.0 and reached to 39.0% in 20 min, achieving a facile intelligent control of chemotherapy additional to the photothermal therapy. The viability of MCF-7/ADR cells could be efficiently reduced to 16.9%, demonstrating the proposed photothermally controlled system with synergistic chemo-photothermal therapy has great potential capability to overcome MDR in breast cancer.

KeywordGold nanoparticles (AuNPs) High dosage of drug loading Intelligent control Synergistic chemo-photothermal therapy Multidrug resistance (MDR)
DOI10.1016/j.colsurfb.2018.11.088
Indexed BySCI
WOS IDWOS:000459837800027
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5686
Collection环境科学与技术研究室
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Lab Environm Sci & Technol, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China
Recommended Citation
GB/T 7714
Wu, XX ,Liu, J ,Yang, LY ,et al. Photothermally controlled drug release system with high dose loading for synergistic chemo-photothermal therapy of multidrug resistance cancer[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,175(3):239-247.
APA Wu, XX ,Liu, J ,Yang, LY ,&Wang, F .(2019).Photothermally controlled drug release system with high dose loading for synergistic chemo-photothermal therapy of multidrug resistance cancer.COLLOIDS AND SURFACES B-BIOINTERFACES,175(3),239-247.
MLA Wu, XX ,et al."Photothermally controlled drug release system with high dose loading for synergistic chemo-photothermal therapy of multidrug resistance cancer".COLLOIDS AND SURFACES B-BIOINTERFACES 175.3(2019):239-247.
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