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Cassiabudanols A and B, Immunostimulative Diterpenoids with a Cassiabudane Carbon Skeleton Featuring a 3-Oxatetracyclo[6.6.1.0(2,6).0(10,14)]pentadecane Scaffold from Cassia Buds
Zhou, HF (Zhou, Haofeng)[ 1 ]; Guoruoluo, Y (Guoruoluo, Yindengzhi)[ 1,2 ]; Tuo, YL (Tuo, Yali)[ 1 ]; Zhou, JF (Zhou, Junfei)[ 1 ]; Zhang, HQ (Zhang, Hanqi)[ 1 ]; Wang, W (Wang, Wei)[ 1 ]; Xiang, M (Xiang, Ming)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 2 ]; Yao, GM (Yao, Guangmin)[ 1 ]
2019
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume21Issue:2Pages:549-553
Abstract

Two novel diterpenoids, cassiabudanols A (1) and B (2), were isolated from cassia buds. Their structures were determined by comprehensive spectroscopic analysis and single-crystal X-ray diffraction. Compounds 1 and 2 possess an unprecedented 11,14-cyclo-8,14:12,13-di-seco-isoryanodane (cassiabudane) carbon skeleton featuring a unique 3-oxatetracyclo-[6.6.1.0(2,6).0(10,14)]pentadecane bridged system, and their biosynthetic pathways are proposed. Compounds 1 and 2 exhibited significant immunostimulative activity, and the mode of action of 2 involves upregulating CD4(+) and CD8(+) T cells and down-regulating Tregs.

DOI10.1021/acs.orglett.8b03883
Indexed BySCI
WOS IDWOS:000456633000043
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5674
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Zhou, HF ,Guoruoluo, Y ,Tuo, YL ,et al. Cassiabudanols A and B, Immunostimulative Diterpenoids with a Cassiabudane Carbon Skeleton Featuring a 3-Oxatetracyclo[6.6.1.0(2,6).0(10,14)]pentadecane Scaffold from Cassia Buds[J]. ORGANIC LETTERS,2019,21(2):549-553.
APA Zhou, HF .,Guoruoluo, Y .,Tuo, YL .,Zhou, JF .,Zhang, HQ .,...&Yao, GM .(2019).Cassiabudanols A and B, Immunostimulative Diterpenoids with a Cassiabudane Carbon Skeleton Featuring a 3-Oxatetracyclo[6.6.1.0(2,6).0(10,14)]pentadecane Scaffold from Cassia Buds.ORGANIC LETTERS,21(2),549-553.
MLA Zhou, HF ,et al."Cassiabudanols A and B, Immunostimulative Diterpenoids with a Cassiabudane Carbon Skeleton Featuring a 3-Oxatetracyclo[6.6.1.0(2,6).0(10,14)]pentadecane Scaffold from Cassia Buds".ORGANIC LETTERS 21.2(2019):549-553.
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