Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits
Gu, DY (Gu, Dongyu)[ 1,2 ]; Yang, Y (Yang, Yi)[ 1 ]; Bakri, M (Bakri, Mahinur)[ 1 ]; Chen, QB (Chen, Qibin)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ]
2018
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
卷号32期号:17页码:2054-2057
摘要

Nitraria sibirica is a traditional Uighur medicine. This study was undertaken to investigate the bioactivity of N. sibirica fruit extract and to evaluate their chemical compositions. The ethyl acetate extract from N. sibirica fruits exhibited the potential antioxidant activity (SC50=30.17 +/- 0.06g/mL) and protein tyrosine phosphatase 1B inhibitory activity (IC50=7.15 +/- 0.03g/mL) in vitro. In order to investigate the active constituents in this extract, a LC-QTOF-MS/MS method was developed and established. A total of 28 compounds including seven cinnamic acids, nine benzoic acids and 12 flavonoids were identified or partially characterised according to the accurate mass and the characteristic fragment ions at low and high collision energy. Most of them were reported for the first time in this plant. Phytochemical profiles of the active extract will help the development and utilisation of N. sibirica in food and medicine.

关键词Nitraria Sibirica Pall Protein Tyrosine Phosphatase 1b Inhibitory Antioxidant Phenolic Constituents Lc-qtof-ms Ms
DOI10.1080/14786419.2017.1359175
收录类别SCI
WOS记录号WOS:000440606000008
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5635
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Aisa, HA (Aisa, Haji Akber)[ 1 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China
2.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian, Peoples R China
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Gu, DY ,Yang, Y ,Bakri, M ,et al. Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits[J]. NATURAL PRODUCT RESEARCH,2018,32(17):2054-2057.
APA Gu, DY ,Yang, Y ,Bakri, M ,Chen, QB ,&Aisa, HA .(2018).Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits.NATURAL PRODUCT RESEARCH,32(17),2054-2057.
MLA Gu, DY ,et al."Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits".NATURAL PRODUCT RESEARCH 32.17(2018):2054-2057.
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