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Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits
Gu, DY (Gu, Dongyu)[ 1,2 ]; Yang, Y (Yang, Yi)[ 1 ]; Bakri, M (Bakri, Mahinur)[ 1 ]; Chen, QB (Chen, Qibin)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 1 ]
2018
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume32Issue:17Pages:2054-2057
Abstract

Nitraria sibirica is a traditional Uighur medicine. This study was undertaken to investigate the bioactivity of N. sibirica fruit extract and to evaluate their chemical compositions. The ethyl acetate extract from N. sibirica fruits exhibited the potential antioxidant activity (SC50=30.17 +/- 0.06g/mL) and protein tyrosine phosphatase 1B inhibitory activity (IC50=7.15 +/- 0.03g/mL) in vitro. In order to investigate the active constituents in this extract, a LC-QTOF-MS/MS method was developed and established. A total of 28 compounds including seven cinnamic acids, nine benzoic acids and 12 flavonoids were identified or partially characterised according to the accurate mass and the characteristic fragment ions at low and high collision energy. Most of them were reported for the first time in this plant. Phytochemical profiles of the active extract will help the development and utilisation of N. sibirica in food and medicine.

KeywordNitraria Sibirica Pall Protein Tyrosine Phosphatase 1b Inhibitory Antioxidant Phenolic Constituents Lc-qtof-ms Ms
DOI10.1080/14786419.2017.1359175
Indexed BySCI
WOS IDWOS:000440606000008
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5635
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)[ 1 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China
2.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Gu, DY ,Yang, Y ,Bakri, M ,et al. Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits[J]. NATURAL PRODUCT RESEARCH,2018,32(17):2054-2057.
APA Gu, DY ,Yang, Y ,Bakri, M ,Chen, QB ,&Aisa, HA .(2018).Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits.NATURAL PRODUCT RESEARCH,32(17),2054-2057.
MLA Gu, DY ,et al."Biological activity and LC-MS profiling of ethyl acetate extracts from Nitraria sibirica (Pall.) fruits".NATURAL PRODUCT RESEARCH 32.17(2018):2054-2057.
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