Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats
Liu, B (Liu, Bing)[ 1,2 ]; Yili, A (Yili, Abulimiti)[ 1,3,4 ]; Aisa, HA (Aisa, Haji Akber)[ 1,3,4 ]; Aikemu, M (Aikemu, Maihesu)[ 5 ]
2018
发表期刊JOURNAL OF FOOD BIOCHEMISTRY
ISSN0145-8884
卷号42期号:5页码:1-9
摘要

In this study, ultrasound-assisted extraction method (UAE) was developed to obtain the protease-rich extract from sheep abomasum (SAE). UAE parameters were first optimized using response surface methodology. Ultrasonic time of 18 min, ultrasonic power of 260 W, and a liquid/solid ratio of 22 mL/g resulted in the highest proteolytic activity and yield of the SAE (4,951.3 U/g, 14.3%, respectively). Then we investigated SAE's gastroprotective effect against gastric ulcers induced by water immersion-restraint stress in rats. After 7 days of intragastric administration of the SAE (0.2 g/kg/day), the ulcer index (2.710.97; p<.05) decreased significantly compared with that in the model group, and the ulcer inhibition ratio was 66.5%. In addition, the response to stress was significantly attenuated by balancing the levels of norepinephrine, 5-hydroxytryptamine, and dopamine in brain regions. Sheep abomasum is the main waste of the sheep meat industry. Converting those wastes to value-added products would be beneficial for both environment and economy. Results of this study presented that UAE resulted in a higher proteolytic activity and yield of SAE with a shorter extraction time than the conventional extraction method. The SAE obtained in this study may be a promising agent for prophylaxis and treatment of stress-induced ulcers.

关键词Gastroprotective Effect Response Surface Methodology Sheep Abomasum Stress-induced Gastric Ulcers Ultrasound-assisted Extraction
DOI10.1111/jfbc.12558
收录类别SCI
WOS记录号WOS:000448178900021
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5630
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Yili, A (Yili, Abulimiti)[ 1,3,4 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Beijing South Rd 40-1, Urumqi 830011, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China
4.Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China
5.Xinjiang Med Univ, Coll Tradit Uighur Med, Urumqi, Peoples R China
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Liu, B ,Yili, A ,Aisa, HA ,et al. Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats[J]. JOURNAL OF FOOD BIOCHEMISTRY,2018,42(5):1-9.
APA Liu, B ,Yili, A ,Aisa, HA ,&Aikemu, M .(2018).Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats.JOURNAL OF FOOD BIOCHEMISTRY,42(5),1-9.
MLA Liu, B ,et al."Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats".JOURNAL OF FOOD BIOCHEMISTRY 42.5(2018):1-9.
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