Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd
Mamat, N (Mamat, Nuramina)[ 1,2 ]; Lu, XY (Lu, Xue Ying)[ 3 ]; Kabas, M (Kabas, Maidina)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 1,3 ]
2018
发表期刊INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN1107-3756
卷号42期号:5页码:2665-2675
摘要

Vitiligo is a depigmentation disorder of the skin. It is primarily caused by the destruction of melanocytes or obstruction of the melanin synthesis pathway. Melanin is a type of skin pigment that determines skin color. The seeds of Vernonia anthelmintica (L.) Willd (Kaliziri) are used for treating skin diseases including vitiligo in traditional Uyghur medicine. 1,5-Dicaffeoylquinic acid (1,5-diCQA) is a natural polyphenolic compound widely distributed in plants and extracted from Kaliziri seeds. Therefore, in the present study, the effect of 1,5-diCQA on melanin synthesis in B16 cell was evaluated, and its molecular mechanism was explored. The results indicated that 1,5-diCQA treatment of B16 cells stimulated an increase of intracellular melanin level and tyrosinase (TYR) activity without cytotoxicity. Reverse transcription quantitative polymerase chain reaction results also indicated that 1,5-diCQA may markedly improve the protein expression and RNA transcription of microphthalmia-associated transcription factor (MITF), melanogenic enzyme Tyr, tyrosinase-related protein 1 (TRP 1) and tyrosinase-related protein 2 (TRP 2). Additional results identified that 1,5-diCQA may promote the phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) MAPK. Notably, the increased levels of intracellular melanin synthesis and tyrosinase expression induced by 1,5-diCQA treatment were significantly attenuated by the protein kinase A (PKA) inhibitor H-89. Intracellular cyclic adenosine monophosphate (cAMP) concentration and phosphorylation of cAMP-response element binding protein was increased following 1,5-diCQA treatment. These results indicated that 1,5-diCQA stimulated melanogenesis via the MAPK and cAMP/PKA signaling pathways in B16 cells, which has potential therapeutic implications for vitiligo.

关键词1 5-dicaffeoylquinic Acid Vitiligo Melanogenesis Mitogen-activated Protein Kinase Signal Pathway
DOI10.3892/ijmm.2018.3861
收录类别SCI
WOS记录号WOS:000447702700031
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5627
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Aisa, HA (Aisa, Haji Akber)[ 1,3 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, 40-1 South Beijing Rd, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
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Mamat, N ,Lu, XY ,Kabas, M ,et al. Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2018,42(5):2665-2675.
APA Mamat, N ,Lu, XY ,Kabas, M ,&Aisa, HA .(2018).Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,42(5),2665-2675.
MLA Mamat, N ,et al."Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 42.5(2018):2665-2675.
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