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Nonenzymatic Glucose Biosensor Based on NiNPs/Nafion/Graphene Film for Direct Glucose Determination in Human Serum
Sukhrobov, P (Sukhrobov, Parviz)[ 1,2 ]; Numonov, S (Numonov, Sodik)[ 1 ]; Gao, SS (Gao, Sanshuang)[ 1 ]; Mamat, X (Mamat, Xamxikamar)[ 1 ]; Wagberg, T (Wagberg, Thomas)[ 3 ]; Guo, YF (Guo, Yufen)[ 4 ]; Liu, LW (Liu, Liwei)[ 4 ]; Hu, GZ (Hu, Guangzhi)[ 1,3 ]
2018
Source PublicationNANO
ISSN1793-2920
Volume13Issue:7Pages:36-47
Abstract

This study describes a type of novel nickel nanoparticles (NiNPs) decorated on Nafiongraphene composite film by using the electrochemical deposition method. It was used to fabricate electrochemical biosensors for sensitive nonenzymatic glucose detection. Compared with the Nafion-graphene film and NiNPs-modified glassy carbon electrode (NiNPs-GCE), the NiNPs/Nafion/graphene/GCE showed the best electrocatalytic activity towards glucose oxidation in alkaline medium. The NiNPs/Nafion/graphene/GCE at an applied potential of +0.55 V in a linear range of 1-200 mu M presented a high sensitivity of 3437.25 mu A center dot mM(-1) cm(-2) with coefficient of correlation R-2 = 0.999; and in a linear range of 200-10800 mu M it performed the best sensitivity of 2848.6 mu A center dot mM(-1) cm(-2) with coefficient of correlation R-2 = 0.995 towards glucose oxidation. For a concentration up to 200 mu M, a linear range was obtained with a limit of detection of 0.6 mu M (signal to noise = 3) and as much as 10 800 mu M with a limit of detection of 0.82 mu M (signal to noise = 3). The time of responses was about 1-1.5 s with the addition of 0.1-1 mM glucose. In addition, NiNPs/Nafion/graphene/GCE also has a high anti-interference ability toward common oxidative interfering species, such as uric acid, ascorbic acid and dopamine. More importantly, NiNPs/Nafion/graphene/GCE was successfully used for the determination of glucose concentration in human serum samples in comparison with a local hospital. The NiNPs/Nafion/graphene/GCE exhibited high sensitivity, low working potential, good stability, excellent electrical properties, enhanced selectivity and fast amperometric responses to glucose oxidation. Thus, as a nonenzymatic sensor, it is promising for future glucose determination development.

KeywordNickel Nanoparticles Graphene Electrodeposition Nonenzymatic Glucose Sensor
DOI10.1142/S1793292018500753
Indexed BySCI
WOS IDWOS:000440354000004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5604
Collection省部共建新疆特有药用资源利用重点实验室
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Umea Univ, Dept Phys, S-90187 Umea, Sweden
4.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion SINANO, Suzhou 215123, Peoples R China
Recommended Citation
GB/T 7714
Sukhrobov, P ,Numonov, S ,Gao, SS ,et al. Nonenzymatic Glucose Biosensor Based on NiNPs/Nafion/Graphene Film for Direct Glucose Determination in Human Serum[J]. NANO,2018,13(7):36-47.
APA Sukhrobov, P .,Numonov, S .,Gao, SS .,Mamat, X .,Wagberg, T .,...&Hu, GZ .(2018).Nonenzymatic Glucose Biosensor Based on NiNPs/Nafion/Graphene Film for Direct Glucose Determination in Human Serum.NANO,13(7),36-47.
MLA Sukhrobov, P ,et al."Nonenzymatic Glucose Biosensor Based on NiNPs/Nafion/Graphene Film for Direct Glucose Determination in Human Serum".NANO 13.7(2018):36-47.
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