Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells
Edirs, S (Edirs, Salamet)[ 1,3 ]; Jiang, L (Jiang, Lan)[ 1,2 ]; Xin, XL (Xin, XueLei)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ]
2018
发表期刊JOURNAL OF PHARMACOLOGICAL SCIENCES
ISSN1347-8613
卷号137期号:2页码:212-219
摘要

Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ on glucose consumption and assess the molecular mechanism on associated proteins in insulin signaling and ER stress pathway in L6 rat skeletal muscle cells. The results showed that, KWZ exhibited proteins of PTP-1B and alpha-glycosidase inhibitory activity in vitro. No cytotoxicity of KWZ was found on L6 cell line. The best effect of glucose consumption of cells was shown at 6.25 mu g/mL after KWZ treatment for 12 h. Expression of PTP-1B protein was inhibited by KWZ in L6 moytubes. PI3K-dependent Akt phosphorylation was found to be activated by KWZ. Moreover, the insulin-mediated induction of IRS-1 and GSK-3 were also activated by KWZ. Western blot results indicated that KWZ significantly improved the levels of ER stress proteins, which reduced the expression of GRP78, enhanced the expression of the PERK, eIF2 alpha and XBP1s. The activation of PERK/eIF2 alpha was likely consequence of GRP78 inhibition, and this might be beneficial for improving the stability of ER and alleviating insulin resistance. These results suggest that KWZ might be serving as the potential drug for the prevention and treatment of T2DM.

关键词Type 2 Diabetes Kursi Wufarikun Ziyabit Anti-diabetic Activity Insulin Signaling Pathway Endoplasmic Reticulum Stress
DOI10.1016/j.jphs.2018.06.011
收录类别SCI
WOS记录号WOS:000440452000015
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5575
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Xin, XL (Xin, XueLei)[ 1,2 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, 40-1 Beijing Rd, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, 40-1 Beijing Rd, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China
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GB/T 7714
Edirs, S ,Jiang, L ,Xin, XL ,et al. Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2018,137(2):212-219.
APA Edirs, S ,Jiang, L ,Xin, XL ,&Aisa, HA .(2018).Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells.JOURNAL OF PHARMACOLOGICAL SCIENCES,137(2),212-219.
MLA Edirs, S ,et al."Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells".JOURNAL OF PHARMACOLOGICAL SCIENCES 137.2(2018):212-219.
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