Identification, synthesis, and control of efinaconazole impurities
Zhu, FQ (Zhu, Fuqiang)[ 1,2 ]; Zhang, J (Zhang, Jian)[ 3 ]; Xiamuxi, H (Xiamuxi, Hainimu)[ 1,2 ]; Chen, WM (Chen, Weiming)[ 1,2 ]; Hu, TW (Hu, Tianwen)[ 3 ]; Yang, XJ (Yang, Xiaojun)[ 3 ]; Tian, GH (Tian, Guanghui)[ 3 ]; Ni, RY (Ni, Runyan)[ 3 ]; Li, J (Li, Jian)[ 3 ]; Suo, J (Suo, Jin)[ 4 ]; Xie, YC (Xie, Yuanchao)[ 4 ]; Shen, JS (Shen, Jingshan)[ 4 ]; Aisa, HA (Aisa, Haji A.)[ 1 ]; He, Y (He, Yang)[ 4 ]
2018
发表期刊PHARMAZIE
ISSN0031-7144
卷号73期号:8页码:438-441
摘要

Impurities A-F were observed, identified, and confirmed during the efinaconazole production process. The possible formation pathways of the mentioned impurities were understood, and thereafter, a controlling strategy was established by locating the proper process parameters with the consideration of efficient cost and less waste as well. This impurity investigation is also essential for quality control of consistently delivering of qualified efinaconazole API.

DOI10.1691/ph.2018.8059
收录类别SCI
WOS记录号WOS:000442458400003
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5570
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Aisa, HA (Aisa, Haji A.)[ 1 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, South Beijing Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Topharman Shanghai Co Ltd, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Zhu, FQ ,Zhang, J ,Xiamuxi, H ,et al. Identification, synthesis, and control of efinaconazole impurities[J]. PHARMAZIE,2018,73(8):438-441.
APA Zhu, FQ .,Zhang, J .,Xiamuxi, H .,Chen, WM .,Hu, TW .,...&He, Y .(2018).Identification, synthesis, and control of efinaconazole impurities.PHARMAZIE,73(8),438-441.
MLA Zhu, FQ ,et al."Identification, synthesis, and control of efinaconazole impurities".PHARMAZIE 73.8(2018):438-441.
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