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Design, Synthesis and Biological Activity of Novel Furocoumarin Derivatives as Stimulators of Melanogenesis and Tyrosinase in B16 Cells
Niu, C (Niu Chao); Zang, D (Zang Deng); Aisa, HA (Aisa, Haji Akber)
2018
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume34Issue:3Pages:408-414
Abstract

Sixteen novel and four known(4a, 4d, 4e, 4h) amine derivatives of furocoumarin were synthesized, then submitted to evaluation as stimulators of melanogenesis and tyrosinase in B16 murine cells. Among them, five compounds(4g, 4j-4m) showed potent activating effect on both melanogenesis and tyrosinase in vitro compared with positive control(8-MOP), the most widely used drugs for vitiligo in clinic. Noticeably, compounds 4h and 4j, which contain morpholine and piperazine, were recognized as the most effective stimulator of melanogenesis and tyrosianse in B16 cells separately. These derivatives may serve as lead compounds for further drug discovery for the treatment of vitiligo.

KeywordFurocoumarin Amine Melanin Synthesis Tyrosinase Vitiligo
DOI10.1007/s40242-018-7338-4
Indexed BySCI
WOS IDWOS:000439929400012
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5524
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Niu, C ,Zang, D ,Aisa, HA . Design, Synthesis and Biological Activity of Novel Furocoumarin Derivatives as Stimulators of Melanogenesis and Tyrosinase in B16 Cells[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2018,34(3):408-414.
APA Niu, C ,Zang, D ,&Aisa, HA .(2018).Design, Synthesis and Biological Activity of Novel Furocoumarin Derivatives as Stimulators of Melanogenesis and Tyrosinase in B16 Cells.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,34(3),408-414.
MLA Niu, C ,et al."Design, Synthesis and Biological Activity of Novel Furocoumarin Derivatives as Stimulators of Melanogenesis and Tyrosinase in B16 Cells".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 34.3(2018):408-414.
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