New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss
Rozimamat, R (Rozimamat, Rushangul); Hu, R (Hu, Rui); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2018
发表期刊FITOTERAPIA
卷号127期号:6页码:328-333
摘要

Three new isopimarane diterpenes and one new nor-triterpenes, along with five known diterpenes were isolated from the whole areal part of Ephorbia alatavica Boiss. The structures of the new compounds (1-4) were determined based on extensive spectroscopic analysis, including HR-ESIMS, 1D and 2D NMR data. A plausible biosynthetic pathway for new compounds (1-4) were hypothesized. All isolated compounds were screen for cytotoxicity activity against MCF-8, HeLa and A549 cell lines in vitro by MIT assay. New compound 1 and known 9 showed potential cytotoxic activities with IC50 values of 15.327 mu g/mL, 23.066 mu g/mL against MCF-8 cell lines, compoundl showed noteworthy cytotoxic activity with IC50 13.033 mu g/mL against A549 cancer cell line. New compounds 2, 4 and 4 showed moderate cytotoxic activities three human cancer lines with IC50 value around 50 mu g/mL, which compared with positive control doxorubicin (DOX).

关键词Euphorbia Alatavica Terpenes Cytotoxicity
DOI10.1016/j.fitote.2018.02.026
收录类别SCI
WOS记录号WOS:000437551000048
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5500
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Rozimamat, R ,Hu, R ,Aisa, HA ,et al. New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss[J]. FITOTERAPIA,2018,127(6):328-333.
APA Rozimamat, R ,Hu, R ,Aisa, HA ,&Aisa, HA.(2018).New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss.FITOTERAPIA,127(6),328-333.
MLA Rozimamat, R ,et al."New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss".FITOTERAPIA 127.6(2018):328-333.
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