XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss
Rozimamat, R (Rozimamat, Rushangul); Hu, R (Hu, Rui); Aisa, HA (Aisa, Haji Akber)
2018
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume127Issue:6Pages:328-333
Abstract

Three new isopimarane diterpenes and one new nor-triterpenes, along with five known diterpenes were isolated from the whole areal part of Ephorbia alatavica Boiss. The structures of the new compounds (1-4) were determined based on extensive spectroscopic analysis, including HR-ESIMS, 1D and 2D NMR data. A plausible biosynthetic pathway for new compounds (1-4) were hypothesized. All isolated compounds were screen for cytotoxicity activity against MCF-8, HeLa and A549 cell lines in vitro by MIT assay. New compound 1 and known 9 showed potential cytotoxic activities with IC50 values of 15.327 mu g/mL, 23.066 mu g/mL against MCF-8 cell lines, compoundl showed noteworthy cytotoxic activity with IC50 13.033 mu g/mL against A549 cancer cell line. New compounds 2, 4 and 4 showed moderate cytotoxic activities three human cancer lines with IC50 value around 50 mu g/mL, which compared with positive control doxorubicin (DOX).

KeywordEuphorbia Alatavica Terpenes Cytotoxicity
DOI10.1016/j.fitote.2018.02.026
Indexed BySCI
WOS IDWOS:000437551000048
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5500
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Rozimamat, R ,Hu, R ,Aisa, HA . New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss[J]. FITOTERAPIA,2018,127(6):328-333.
APA Rozimamat, R ,Hu, R ,&Aisa, HA .(2018).New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss.FITOTERAPIA,127(6),328-333.
MLA Rozimamat, R ,et al."New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss".FITOTERAPIA 127.6(2018):328-333.
Files in This Item:
File Name/Size DocType Version Access License
New isopimarane dite(818KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Rozimamat, R (Rozimamat, Rushangul)]'s Articles
[Hu, R (Hu, Rui)]'s Articles
[Aisa, HA (Aisa, Haji Akber)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Rozimamat, R (Rozimamat, Rushangul)]'s Articles
[Hu, R (Hu, Rui)]'s Articles
[Aisa, HA (Aisa, Haji Akber)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Rozimamat, R (Rozimamat, Rushangul)]'s Articles
[Hu, R (Hu, Rui)]'s Articles
[Aisa, HA (Aisa, Haji Akber)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: New isopimarane diterpenes and nortriterpene with cytotoxic activity from Ephorbia alatavica Boiss.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.