Robustanoids A and B, two novel pyrrolo[2,3-b] indole alkaloids from Coffea canephora: isolation and total synthesis
Han, JX (Han, Jianxin); Niu, ST (Niu, Sheng-Tong); Liu, YS (Liu, Yushuang); Gan, LS (Gan, Lishe); Wang, TF (Wang, Tianfu); Lu, CD (Lu, Chong-Dao); Yuan, T (Yuan, Tao)
2018
发表期刊ORGANIC CHEMISTRY FRONTIERS
ISSN2052-4129
卷号5期号:4页码:586-589
摘要

Two novel pyrrolo[ 2,3-b] indole alkaloids, named robustanoids A (1) and B (2), featuring an unprecedented 1,2,3,4,8b, 8c-hexahydro-2a, 4a-diazapentaleno[1,6-ab] indene moiety, were isolated from Coffea canephora beans. Their structures were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. The total synthesis of compounds 1 and 2 was successfully conducted to give a decent total yield (similar to 29%) in 8 steps, which also confirmed the structures determined by spectroscopic data. Compound 2 showed alpha-glucosidase inhibitory activity comparable to that of the positive control, acarbose.

DOI10.1039/c7qo00931c
收录类别SCI
WOS记录号WOS:000431292400012
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5487
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Lu, CD (Lu, Chong-Dao); Yuan, T (Yuan, Tao)
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
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Han, JX ,Niu, ST ,Liu, YS ,et al. Robustanoids A and B, two novel pyrrolo[2,3-b] indole alkaloids from Coffea canephora: isolation and total synthesis[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(4):586-589.
APA Han, JX .,Niu, ST .,Liu, YS .,Gan, LS .,Wang, TF .,...&Yuan, T .(2018).Robustanoids A and B, two novel pyrrolo[2,3-b] indole alkaloids from Coffea canephora: isolation and total synthesis.ORGANIC CHEMISTRY FRONTIERS,5(4),586-589.
MLA Han, JX ,et al."Robustanoids A and B, two novel pyrrolo[2,3-b] indole alkaloids from Coffea canephora: isolation and total synthesis".ORGANIC CHEMISTRY FRONTIERS 5.4(2018):586-589.
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