A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.
Liu, Xixi; Aisa, Haji Akber; Xin, Xuelei
2017
发表期刊Natural product research
期号10页码:1-5
摘要

A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38±0.14muM in vitro.

关键词Nigella Sativa Var. Hispidula Anti-ptp1b Activity Fatty Acid Ester Phenolic Compounds
DOI10.1080/14786419.2017.1396594
收录类别SCI
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5485
专题省部共建新疆特有药用资源利用重点实验室
作者单位a Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi , PR China.
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Liu, Xixi,Aisa, Haji Akber,Xin, Xuelei. A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.[J]. Natural product research,2017(10):1-5.
APA Liu, Xixi,Aisa, Haji Akber,&Xin, Xuelei.(2017).A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity..Natural product research(10),1-5.
MLA Liu, Xixi,et al."A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.".Natural product research .10(2017):1-5.
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