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A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.
Liu, XX (Liu, Xixi)[ 1,2,3 ]; Aisa, HA (Aisa, Haji Akber)[ 1,2 ]; Xin, XL (Xin, Xuelei)[ 1,2 ]
2019
Source PublicationNatural product research
ISSN1478-6419
Volume33Issue:4Pages:472-476
Abstract

A new fatty acid ester (1) and seven known phenolic compounds, i.e. salfredin B11 (2), nigephenol C (3), nigephenol B (4), acetovanillion (5), p-hydroxybenzoic acid (6), p-hydroxy-acetophenone (7) and p-hydroxybenzaldehyde (8), were isolated from the seeds of Nigella sativa var. hispidula. Among them, compounds 5, 7 and 8 were isolated from Nigella for the first time. Their structures were elucidated with HR-ESI-MS, 1D and 2D NMR spectra. Evaluation of the isolated compounds on protein tyrosine phosphatase (PTP1B) assay indicated that although compounds 2-8 show no promising anti-PTP1B activities, compound 1 possess anti-PTP1B activity with an IC50 value of 7.38±0.14muM in vitro.

KeywordNigella sativa var hispidula fatty acid ester phenolic compounds anti-PTP1B activity
DOI10.1080/14786419.2017.1396594
Indexed BySCI
WOS IDWOS:000465153400003
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5485
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorXin, XL (Xin, Xuelei)[ 1,2 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China
3.Univ Chinese Acad Sci, Beijing, PR, Peoples R China
Recommended Citation
GB/T 7714
Liu, XX ,Aisa, HA ,Xin, XL . A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.[J]. Natural product research,2019,33(4):472-476.
APA Liu, XX ,Aisa, HA ,&Xin, XL .(2019).A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity..Natural product research,33(4),472-476.
MLA Liu, XX ,et al."A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.".Natural product research 33.4(2019):472-476.
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