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Angustifolinoid A, a macrocyclic flavonoid glycoside from Elaeagnus angustifolia flowers
Chen, XY (Chen, Xiaoyu); Liu, YS (Liu, Yushuang); Chen, GY (Chen, Guangying); Gong, C (Gong, Chi); Li, SG (Li, Shengge); Hua, HM (Hua, Huiming); Yuan, T (Yuan, Tao)
2018
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume59Issue:26Pages:2610-2613
Abstract

A novel macrocyclic flavonoid glycoside, angustifolinoid A (1), featuring an unprecedented 13-membered heterocyclic ring moiety, along with a known flavonoid glycoside, tiliroside (2), were isolated from Elaeagnus angustifolia flowers. Their structures were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Biosynthesis analysis indicated that compound 1 might be derived from compound 2 via a key enzymatic intramolecular oxidative coupling. Compounds 1 and 2 showed inhibitory activities against cyclooxygenases, COX-1 and COX-2.

KeywordAngustifolinoid Flavonoid Glycoside Elaeagnus Angustifolia Oxidative Coupling Cyclooxygenase
DOI10.1016/j.tetlet.2018.05.074
Indexed BySCI
WOS IDWOS:000436221100027
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5477
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorYuan, T (Yuan, Tao)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Hainan, Peoples R China
3.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, XY ,Liu, YS ,Chen, GY ,et al. Angustifolinoid A, a macrocyclic flavonoid glycoside from Elaeagnus angustifolia flowers[J]. TETRAHEDRON LETTERS,2018,59(26):2610-2613.
APA Chen, XY .,Liu, YS .,Chen, GY .,Gong, C .,Li, SG .,...&Yuan, T .(2018).Angustifolinoid A, a macrocyclic flavonoid glycoside from Elaeagnus angustifolia flowers.TETRAHEDRON LETTERS,59(26),2610-2613.
MLA Chen, XY ,et al."Angustifolinoid A, a macrocyclic flavonoid glycoside from Elaeagnus angustifolia flowers".TETRAHEDRON LETTERS 59.26(2018):2610-2613.
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