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Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway
Liu, L (Liu, Liu); Yasen, M (Yasen, Mireguli); Tang, D (Tang, Dan); Ye, JP (Ye, Jianping); Aisa, HA (Aisa, Haji Akber); Xin, XL (Xin, Xuelei)
2018
Source PublicationBIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
Volume100Issue:4Pages:29-35
Abstract

This study was designed to investigate the mechanism of polyphenol-enriched extract of Rosa rugosa Thunb (RPE) in the control of dyslipidemia in diabetic rats. RPE was tested at three dosages (37.5 mg/kg, 75 mg/kg and 150 mg/kg) in the rat dyslipidemia model established with high fat diet feeding in combination with STZ injection (30 mg/kg). The RPE effect was evaluated after 4 weeks of treatment. In the RPE-treated rats, hepatic total cholesterol (TC) and triglyceride (TG) were significantly reduced, lipoprotein lipase (LPL) and liver lipase (HL) were significantly increased. The levels of alanine transaminase (ALT) and aspartate transaminase (AST) were decreased in the serum. Those effects of RPE were observed primarily at the mediate and high dosages. Expression of FGF21 was increased in the liver tissue and hepatic cell line 1c1c7 by RPE. The signals of p-AMPK, p-ACC, ACC, p-SIRT, and PGC-1 alpha were significantly induced in the liver by RPE. The results suggest that RPE may improve hepatic steatosis and liver function by induction of AMPK signaling activity in the control of dyslipidemia.

KeywordRosa Rugosa Thunb Diabetes Dyslipidemia Mechanism
DOI10.1016/j.biopha.2018.01.143
Indexed BySCI
WOS IDWOS:000427649200005
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5257
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorXin, XL (Xin, Xuelei)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Louisisana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA
Recommended Citation
GB/T 7714
Liu, L ,Yasen, M ,Tang, D ,et al. Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,100(4):29-35.
APA Liu, L ,Yasen, M ,Tang, D ,Ye, JP ,Aisa, HA ,&Xin, XL .(2018).Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway.BIOMEDICINE & PHARMACOTHERAPY,100(4),29-35.
MLA Liu, L ,et al."Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway".BIOMEDICINE & PHARMACOTHERAPY 100.4(2018):29-35.
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