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Synthesis of Rupestonic Acid Amide Derivatives and in vitro Anti-influenza A(3), B and Herpes Simplex Type I and II Viruses
Yong, JP (Yong Jian-Ping); Haji, AA (Haji Akber Aisa)
2008
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
ISSN0253-2786
Volume28Issue:10Pages:1807-1812
Abstract

The rupestonic acid (compound 1) was isolated from the Chinese herbal medicine Artemisia rupestris L. (its Chinese name being Yizhihao). Then, 13 rupestonic acid amide derivatives 2a similar to 2m were synthesized using rupestonic acid and organic amines in the presence of DCC, HOBt/DMAP and their structures were comfirmed by the methods of IR, (1)HNMR, and ESI-MS. All compounds were preliminarily assayed in vitro against influenza A(3), B, herpes simplex I (HSV-I) and herpes simplex II (HSV-II) viruses, showing that 2a was inhibitive to both influenza A(3) and B viruses, and had the higher inhibition against influenza B virus than the parent compound 1. The inhibition of 2d against influenza B virus was 16-fold higher than that of the parent compound and 2e was more active both to HSV-I and HSV-II viruses

KeywordSynthesis Rupestonic Acid Amide Derivative Influenza a(3) b Virus Herpes Simplex Virus Biological Activity
Indexed BySCI
WOS IDWOS:000260865100022
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5245
Collection资源化学研究室
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yong, JP ,Haji, AA . Synthesis of Rupestonic Acid Amide Derivatives and in vitro Anti-influenza A(3), B and Herpes Simplex Type I and II Viruses[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2008,28(10):1807-1812.
APA Yong, JP ,&Haji, AA .(2008).Synthesis of Rupestonic Acid Amide Derivatives and in vitro Anti-influenza A(3), B and Herpes Simplex Type I and II Viruses.CHINESE JOURNAL OF ORGANIC CHEMISTRY,28(10),1807-1812.
MLA Yong, JP ,et al."Synthesis of Rupestonic Acid Amide Derivatives and in vitro Anti-influenza A(3), B and Herpes Simplex Type I and II Viruses".CHINESE JOURNAL OF ORGANIC CHEMISTRY 28.10(2008):1807-1812.
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