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Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity
Liu, YS (Liu, Yushuang); Xue, JJ (Xue, Jingjing); Han, JX (Han, Jianxin); Hua, HM (Hua, Huiming); Yuan, T (Yuan, Tao)
2018
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume23Issue:2Pages:168-171
Abstract

Two new polyacetylenes, (2R, 11S, 12S)-(3E)-tridecene-5,7,9-triyne-1,2,11,12-tetraol (1) and (8S)-deca-4,6-diyne-1,8-diol-8-O-beta-D-glucopyranoside (2), together with six known polyacetylenes (3-8), were isolated from the florets of Carthamus tinctorius. Their structures were elucidated on the basis of spectroscopic data (NMR and HRMS) and Mo2(OAc) 4-induced circular dichroism. Compounds 4 and 5 were cytotoxic to the human cancer cell lines HL-60 (IC50=6.40, 3.66 mu M), THP-1 (IC50=8.67, 6.69 mu M) and PC-3 (IC50=11.30, 10.92 mu M), comparable to the positive control, fluorouracil (IC50=2.58, 3.95 and 22.35 mu M, respectively).

KeywordCarthamus Tinctorius Compositae Polyacetylenes Circular Dichroism Cytotoxicity
DOI10.1016/j.phytol.2017.12.006
Indexed BySCI
WOS IDWOS:000426096600031
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5240
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorYuan, T (Yuan, Tao)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Liu, YS ,Xue, JJ ,Han, JX ,et al. Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity[J]. PHYTOCHEMISTRY LETTERS,2018,23(2):168-171.
APA Liu, YS ,Xue, JJ ,Han, JX ,Hua, HM ,&Yuan, T .(2018).Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity.PHYTOCHEMISTRY LETTERS,23(2),168-171.
MLA Liu, YS ,et al."Polyacetylenes from the florets of Carthamus tinctorius and their cytotoxicity".PHYTOCHEMISTRY LETTERS 23.2(2018):168-171.
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