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Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species
Liu, WX (Liu, Weixi); Ma, H (Ma, Hang); Frost, L (Frost, Leslie); Yuan, T (Yuan, Tao); Dain, JA (Dain, Joel A.); Seeram, NP (Seeram, Navindra P.)
2014
发表期刊FOOD & FUNCTION
卷号5期号:5页码:2996-3004
摘要

Advanced Glycation Endproducts (AGEs) are a heterogeneous group of molecules produced from nonenzymatic glycation. Accumulation of AGEs in vivo plays an important role in the pathology of chronic human diseases including type-2 diabetes and Alzheimer's disease. Natural AGEs inhibitors such as the pomegranate (Punica granatum) fruit show great potential for the management of these diseases. Herein, we investigated the in vitro anti-glycation effects of a pomegranate fruit extract (PE), its phenolic constituents [punicalagin (PA), ellagic acid (EA) and gallic acid (GA)], and their in vivo derived colonic metabolites [urolithin A (UA) and urolithin B (UB)]. All of the samples showed anti-glycation activities and PE, PA, and EA were more potent inhibitors than the positive control, aminoguanidine. PE and the purified phenolics also exhibited carbonyl scavenger reactivity. Our study suggests that pomegranate may offer an attractive dietary strategy for the prevention and treatment of AGE-related diseases such as type-2 diabetes and Alzheimer's disease.

DOI10.1039/c4fo00538d
收录类别SCI
WOS记录号WOS:000344320600032
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5200
专题资源化学研究室
作者单位1.Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA
2.Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA
3.Marshall Univ, Dept Chem, Huntington, WV 25755 USA
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Liu, WX ,Ma, H ,Frost, L ,et al. Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species[J]. FOOD & FUNCTION,2014,5(5):2996-3004.
APA Liu, WX ,Ma, H ,Frost, L ,Yuan, T ,Dain, JA ,&Seeram, NP .(2014).Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species.FOOD & FUNCTION,5(5),2996-3004.
MLA Liu, WX ,et al."Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species".FOOD & FUNCTION 5.5(2014):2996-3004.
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