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Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles
Yan, Y (Yan, Yue); Fu, J (Fu, Jie); Liu, X (Liu, Xin); Wang, TF (Wang, Tianfu); Lu, XY (Lu, Xiuyang)
2015
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume5Issue:39Pages:30640-30646
Abstract

Anti-tumor drug doxorubicin has been successfully anchored onto MCM-41-type mesoporous silica nanoparticles (MSNs) with acid-cleavable citraconic bond to afford the hybrid Dox-MSN nanomedicine. "click chemistry" has been exploited as an effective method for doxorubicin conjugation. Under normal plasma pH conditions (pH = 7.4), doxorubicin was covalently tethered to the surface of MSNs, avoiding premature drug release when unnecessary. After exposure to acidic microenvironment, such as encountered in cancerous tissue or intracellular compartment endosome, the acid-labile citraconic bond was decomposed, releasing the active pharmaceutical ingredient, doxorubicin. The kinetic profiles of doxorubicin release have been studied under different pH conditions (ranging from 4 to 7.4), clearly indicating a pH-dependent controlled release behavior. MTT assay with human cervical cancer cells (HeLa) and confocal microscopy were used to study the anti-tumor activity and particle uptake behavior of Dox-MSN, respectively. A multitude of physicochemical analytical methods, including TEM, SEM, XRD, porosity analysis, IR spectroscopy, confirmed the successful fabrication of desired MSNs. These acidresponsive MSNs can be speculated to find wide ranging applications as nano-carriers in biomedical research, especially for targeted anticancer drug delivery.

DOI10.1039/c5ra00059a
Indexed BySCI
WOS IDWOS:000352791300032
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5188
Collection资源化学研究室
Affiliation1.Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Zhejiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Yan, Y ,Fu, J ,Liu, X ,et al. Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles[J]. RSC ADVANCES,2015,5(39):30640-30646.
APA Yan, Y ,Fu, J ,Liu, X ,Wang, TF ,&Lu, XY .(2015).Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles.RSC ADVANCES,5(39),30640-30646.
MLA Yan, Y ,et al."Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles".RSC ADVANCES 5.39(2015):30640-30646.
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