XJIPC OpenIR  > 资源化学研究室
Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles
Yan, Y (Yan, Yue); Fu, J (Fu, Jie); Liu, X (Liu, Xin); Wang, TF (Wang, Tianfu); Lu, XY (Lu, Xiuyang)
2015
发表期刊RSC ADVANCES
卷号5期号:39页码:30640-30646
摘要

Anti-tumor drug doxorubicin has been successfully anchored onto MCM-41-type mesoporous silica nanoparticles (MSNs) with acid-cleavable citraconic bond to afford the hybrid Dox-MSN nanomedicine. "click chemistry" has been exploited as an effective method for doxorubicin conjugation. Under normal plasma pH conditions (pH = 7.4), doxorubicin was covalently tethered to the surface of MSNs, avoiding premature drug release when unnecessary. After exposure to acidic microenvironment, such as encountered in cancerous tissue or intracellular compartment endosome, the acid-labile citraconic bond was decomposed, releasing the active pharmaceutical ingredient, doxorubicin. The kinetic profiles of doxorubicin release have been studied under different pH conditions (ranging from 4 to 7.4), clearly indicating a pH-dependent controlled release behavior. MTT assay with human cervical cancer cells (HeLa) and confocal microscopy were used to study the anti-tumor activity and particle uptake behavior of Dox-MSN, respectively. A multitude of physicochemical analytical methods, including TEM, SEM, XRD, porosity analysis, IR spectroscopy, confirmed the successful fabrication of desired MSNs. These acidresponsive MSNs can be speculated to find wide ranging applications as nano-carriers in biomedical research, especially for targeted anticancer drug delivery.

DOI10.1039/c5ra00059a
收录类别SCI
WOS记录号WOS:000352791300032
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5188
专题资源化学研究室
作者单位1.Zhejiang Univ, Coll Chem & Biol Engn, Key Lab Biomass Chem Engn, Minist Educ, Hangzhou 310027, Zhejiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
推荐引用方式
GB/T 7714
Yan, Y ,Fu, J ,Liu, X ,et al. Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles[J]. RSC ADVANCES,2015,5(39):30640-30646.
APA Yan, Y ,Fu, J ,Liu, X ,Wang, TF ,&Lu, XY .(2015).Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles.RSC ADVANCES,5(39),30640-30646.
MLA Yan, Y ,et al."Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles".RSC ADVANCES 5.39(2015):30640-30646.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Acid-responsive intr(797KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yan, Y (Yan, Yue)]的文章
[Fu, J (Fu, Jie)]的文章
[Liu, X (Liu, Xin)]的文章
百度学术
百度学术中相似的文章
[Yan, Y (Yan, Yue)]的文章
[Fu, J (Fu, Jie)]的文章
[Liu, X (Liu, Xin)]的文章
必应学术
必应学术中相似的文章
[Yan, Y (Yan, Yue)]的文章
[Fu, J (Fu, Jie)]的文章
[Liu, X (Liu, Xin)]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。