Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Gu, DY (Gu, Dongyu); Yang, Y (Yang, Yi); Chen, QB (Chen, Qibin); Habasi, M (Habasi, Madina); Zhao, JY (Zhao, Jiangyu); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2015
发表期刊BIOMEDICAL CHROMATOGRAPHY
卷号29期号:4页码:595-603
摘要

Rupestonic acid, a potential anti-influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well-known traditional Uighur medicine for the treatment of colds. In the present study, high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid.

关键词Rupestonic Acid Artemisia Rupestris l Traditional Uighur Medicine Metabolites Lc Qtof-ms Ms Antivirus Agent
DOI10.1002/bmc.3319
收录类别SCI
WOS记录号WOS:000352094800016
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5166
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
2.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
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Gu, DY ,Yang, Y ,Chen, QB ,et al. Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2015,29(4):595-603.
APA Gu, DY .,Yang, Y .,Chen, QB .,Habasi, M .,Zhao, JY .,...&Aisa, HA.(2015).Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,29(4),595-603.
MLA Gu, DY ,et al."Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 29.4(2015):595-603.
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