XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
Gu, DY (Gu, Dongyu); Yang, Y (Yang, Yi); Chen, QB (Chen, Qibin); Habasi, M (Habasi, Madina); Zhao, JY (Zhao, Jiangyu); Aisa, HA (Aisa, Haji Akber)
2015
Source PublicationBIOMEDICAL CHROMATOGRAPHY
ISSN0269-3879
Volume29Issue:4Pages:595-603
Abstract

Rupestonic acid, a potential anti-influenza agent, is an important and characteristic compound in Artemisia rupestris L., a well-known traditional Uighur medicine for the treatment of colds. In the present study, high-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry was used to detect and identify the metabolites in rat urine after oral administration of rupestonic acid. A total of 10 metabolites were identified or partially characterized. The structure elucidations of the metabolites were performed by comparing the changes in accurate molecular masses and fragment ions with those of the parent compound. The results showed that the main metabolites of rupestonic acid in rat urine were formed by oxidation, hydrogenation and glucuronidation. A metabolism pathway was proposed for the first time based on the characterized structures. This metabolism study can provide essential information for drug discovery, design and clinical application of rupestonic acid.

KeywordRupestonic Acid Artemisia Rupestris l Traditional Uighur Medicine Metabolites Lc Qtof-ms Ms Antivirus Agent
DOI10.1002/bmc.3319
Indexed BySCI
WOS IDWOS:000352094800016
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5166
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
2.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Gu, DY ,Yang, Y ,Chen, QB ,et al. Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry[J]. BIOMEDICAL CHROMATOGRAPHY,2015,29(4):595-603.
APA Gu, DY ,Yang, Y ,Chen, QB ,Habasi, M ,Zhao, JY ,&Aisa, HA .(2015).Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.BIOMEDICAL CHROMATOGRAPHY,29(4),595-603.
MLA Gu, DY ,et al."Identification of metabolites of rupestonic acid in rat urine by liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry".BIOMEDICAL CHROMATOGRAPHY 29.4(2015):595-603.
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