XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.
Jiang, L (Jiang, Lan); Numonov, S (Numonov, Sodik); Bobakulov, K (Bobakulov, Khayrulla); Qureshi, MN (Qureshi, Muhammad Nasimullah); Zhao, HQ (Zhao, Haiqing); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2015
Source PublicationMOLECULES
Volume20Issue:6Pages:11257-11271
Abstract

Phytochemical investigations of ethyl acetate-soluble part of the aerial part of Hypericum scabrum L. delivered eight pure phenolic compounds 1-8. The pure compounds were identified through physico-chemical, NMR (1D, 2D) and mass spectrometric studies as: 3-8-bisapigenin (1), quercetin (2), quercetin-3-O--l-arabinofuranoside (3), quercetin-3-O--l-rhamnoside (4), quercetin-3-O--d-glucopyranoside (5), quercetin-3-O--d-galactopyranoside (6), (-)-epicatechin (7), (+)-catechin (8). Total polyphenolic compounds and total flavonoids contents were determined in the extract as 0.107 mg.mg(-1) and 0.023 mg.mg(-1) of the dried extract, respectively. Antioxidant activity using DPPH free radical scavenging assay delivered very strong activity for compounds 2 and 5, 6 and crude extract 10. Protein tyrosine phosphatase 1B (PTP-1B) inhibition experiment of isolated compounds and crude extracts resulted in significant inhibition activity for samples 2, 7a, 8a, 11 and 12 with IC50 values ranging from 1.57 to 2.91 mu M. Antimicrobial activity of the pure compounds and extracts produced average results against Staphylococcus aureus, Escherichia coli and Candida albicans strains. From our literature survey, it appears that all pure compounds except 2 were isolated and reported for the first time in H. scabrum.

KeywordHypericum Scabrum l Ethylacetate Fraction Column Chromatography Nmr Esi-ms Antidiabetic Activity Antioxidant Activity Antimicrobial Activity
DOI10.3390/molecules200611257
Indexed BySCI
WOS IDWOS:000357992700108
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5157
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Acad Sci Republ Tajikistan, State Sci Expt & Prod Org, Dushanbe 734063, Tajikistan
5.Acad Sci Uzbek, Inst Chem Plant Subst, Tashkent 100170, Uzbekistan
6.Abdul Wali Khan Univ Mardan, Dept Chem, Mardan 23200, Pakistan
Recommended Citation
GB/T 7714
Jiang, L ,Numonov, S ,Bobakulov, K ,et al. Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.[J]. MOLECULES,2015,20(6):11257-11271.
APA Jiang, L .,Numonov, S .,Bobakulov, K .,Qureshi, MN .,Zhao, HQ .,...&Aisa, HA.(2015).Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L..MOLECULES,20(6),11257-11271.
MLA Jiang, L ,et al."Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.".MOLECULES 20.6(2015):11257-11271.
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