Elemanolide dimers from seeds of Vernonia anthelmintica
Turak, A (Turak, Ablajan); Liu, YQ (Liu, Yongqiang); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2015
发表期刊FITOTERAPIA
卷号104期号:7页码:23-30
摘要

The seeds of Vernonia anthelmintica afforded three new elemanolide dimers, vemodalidimers C, D, and E, and four known elemanolides. Their structures were elucidated based on extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations of the new dimers were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolated compounds against four human tumor cell lines was assayed. Vernodalidimers C, D, and E exhibited strong cytotoxicity against T47D cell line with IC50 values of 5.58, 0.95, and 12.75 mu M, respectively.

关键词Vernonia Anthelmintica Sesquiterpenes Elemanolide Dimers Cytotoxicity Ecd
DOI10.1016/j.fitote.2015.04.013
收录类别SCI
WOS记录号WOS:000357547100004
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5155
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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Turak, A ,Liu, YQ ,Aisa, HA ,et al. Elemanolide dimers from seeds of Vernonia anthelmintica[J]. FITOTERAPIA,2015,104(7):23-30.
APA Turak, A ,Liu, YQ ,Aisa, HA ,&Aisa, HA.(2015).Elemanolide dimers from seeds of Vernonia anthelmintica.FITOTERAPIA,104(7),23-30.
MLA Turak, A ,et al."Elemanolide dimers from seeds of Vernonia anthelmintica".FITOTERAPIA 104.7(2015):23-30.
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