XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Elemanolide dimers from seeds of Vernonia anthelmintica
Turak, A (Turak, Ablajan); Liu, YQ (Liu, Yongqiang); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2015
Source PublicationFITOTERAPIA
Volume104Issue:7Pages:23-30
Abstract

The seeds of Vernonia anthelmintica afforded three new elemanolide dimers, vemodalidimers C, D, and E, and four known elemanolides. Their structures were elucidated based on extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations of the new dimers were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolated compounds against four human tumor cell lines was assayed. Vernodalidimers C, D, and E exhibited strong cytotoxicity against T47D cell line with IC50 values of 5.58, 0.95, and 12.75 mu M, respectively.

KeywordVernonia Anthelmintica Sesquiterpenes Elemanolide Dimers Cytotoxicity Ecd
DOI10.1016/j.fitote.2015.04.013
Indexed BySCI
WOS IDWOS:000357547100004
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5155
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Turak, A ,Liu, YQ ,Aisa, HA ,et al. Elemanolide dimers from seeds of Vernonia anthelmintica[J]. FITOTERAPIA,2015,104(7):23-30.
APA Turak, A ,Liu, YQ ,Aisa, HA ,&Aisa, HA.(2015).Elemanolide dimers from seeds of Vernonia anthelmintica.FITOTERAPIA,104(7),23-30.
MLA Turak, A ,et al."Elemanolide dimers from seeds of Vernonia anthelmintica".FITOTERAPIA 104.7(2015):23-30.
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