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Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties
Bozorov, K (Bozorov, Khurshed); Zhao, JY (Zhao, Jiang-Yu); Elmuradov, B (Elmuradov, Burkhon); Pataer, A (Pataer, Apar); Aisa, HA (Aisa, Haji A.); Aisa, HA
2015
Source PublicationEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume102Issue:9Pages:552-573
Abstract

It is generally understood that the antitumor properties of synthetic heterocyclic compounds are among the most powerful properties that can be made use in medicinal chemistry. More specifically, their substantial cytotoxic effects against different types of human tumor cells, in addition to their roles as enzymes or receptors for various kinase inhibitors, make them critically important. In recent years, thieno[2,3-d]pyrimidin-4-one derivatives (TPs), which are analogs of quinazoline alkaloids, have frequently attracted the interest of medicinal chemistry researchers due to their promising anticancer properties. The present study is a review of the latest advances (i.e., since 2006) in TP derivative-related research, with a focus on how such derivatives are synthesized and on their anticancer activities.

KeywordSynthesis Thieno[2 Anticancer 3-d]Pyrimidin-4-one Derivatives Cytotoxic Effect Kinase Inhibitors
DOI10.1016/j.ejmech.2015.08.018
Indexed BySCI
WOS IDWOS:000361922600046
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5139
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Xinjiang, Peoples R China
2.Acad Sci Uzbek, Inst,Chem Plant Subst, Tashkent 100170, Uzbekistan
3.Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Bozorov, K ,Zhao, JY ,Elmuradov, B ,et al. Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015,102(9):552-573.
APA Bozorov, K ,Zhao, JY ,Elmuradov, B ,Pataer, A ,Aisa, HA ,&Aisa, HA.(2015).Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,102(9),552-573.
MLA Bozorov, K ,et al."Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 102.9(2015):552-573.
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