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New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice
Zhang, Y (Zhang, Yan); Ma, H (Ma, Hang); Liu, WX (Liu, Weixi); Yuan, T (Yuan, Tao); Seeram, NP (Seeram, Navindra P.); Yuan, T
2015
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume63Issue:45Pages:10097-10102
Abstract

Cumin (Cuminum cyminum L.), a widely consumed food spice, has been reported to have antiglycative effects in vitro and in vivo, but there is a paucity of data on its bioactive compounds. Herein, we report the isolation and structure elucidation (by NMR, HRESIMS, and CD) of 21 (1-21) compounds from a methanol extract of cumin seeds. The isolates included five new compounds: two sesquiterpenoids, two pairs of monoterpeneoid epimers, and a chalcone, named cuminoids A-E, respectively. The isolates were evaluated for antiglycative effects using the bovine serum albumin-fructose intrinsic fluorescence assay. At equivalent concentrations, several of the isolates, including cuminoids C-E, were more potent inhibitors than the positive control, aminoguanidine, a synthetic antiglycative agent (>50 vs 35%, respectively).

KeywordCuminum Cyminum Cumin Cuminoids Advanced Glycation Endproducts Antiglycative Bioactive
DOI10.1021/acs.jafc.5b04796
Indexed BySCI
WOS IDWOS:000366004800001
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5131
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorYuan, T
Affiliation1.Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA
2.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Y ,Ma, H ,Liu, WX ,et al. New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2015,63(45):10097-10102.
APA Zhang, Y ,Ma, H ,Liu, WX ,Yuan, T ,Seeram, NP ,&Yuan, T.(2015).New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,63(45),10097-10102.
MLA Zhang, Y ,et al."New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 63.45(2015):10097-10102.
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