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Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients
Aibai, S (Aibai, Silafu); Anzhaer, A (Anzhaer, Aikebaier); Aimaiti, A (Aimaiti, Ayinuer); Islama, R (Islama, Rabigul); Aimaiti, G (Aimaiti, Gulisitan); Abuduaini, A (Abuduaini, Abudujilili)
2015
发表期刊EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
卷号7期号:6页码:653-656
摘要

Introduction: Traditional Uighur medicine humoral (Hilit) theory recognises six different syndrome types of vitiligo. Levels of cytokines, hormones and neurotransmitters relevant to vitiligo were measured in patients diagnosed according to Uighur medicine criteria, in order to identify any association between biochemical parameters and the six syndromes identified by traditional differential diagnosis. Methods: Using ELISA, interferon-gamma (IFN-gamma), soluble intercellular adhesion molecule 1 (sICAM-1), tyrosine enzyme antibody IgG (IgG), 5-hydroxytryptamine (5-HT), cortisol and norepinephrine (NE) levels were measured in peripheral blood serum of 90 healthy adults, and in serum and skin lesional tissue fluid of 450 vitiligo patients. Large sample multi-angle correlation analysis was used to compare data between patients and non-vitiligo suffers and between patients in the six vitiligo syndrome groups. Results: Analysis of biochemical parameters showed that serum levels of sICAM-1, IgG and especially IFNgamma, were higher in patients than in controls, whereas cortisol levels were lower (IFN-gamma, P = 0.017; sICAM-1, P = 0.000; IgG, P = 0.025; cortisol, P = 0.000). IFN-gamma, cortisol, IgG and NE levels were lower in serum than in skin lesional tissue fluid, whereas 5-HT was higher in serum (IFN-gamma, P = 0.000; cortisol, P = 0.000; IgG, P = 0.034; NE, P = 0.000; 5-HT, P = 0.000). There were no differences in serum indicators between syndromes but in skin lesional tissue fluid, IFN-gamma, 5-HT and IgG levels showed significant differences between types, Conclusion: Increased levels of IFN-gamma are associated with the development of vitiligo. The traditional Uighur dialectical typing of vitiligo into six different syndromes is supported by changes in levels of cytokines in skin lesional tissue fluid, but not serum.

关键词Vitiligo Cytokine Ifn-gamma Sicam-1 Igg Cortisol 5-hydroxytryptamine And Norepinephrine Uighur Medicine
DOI10.1016/j.eujim.2015.10.010
收录类别SCI
WOS记录号WOS:000366909200015
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5129
专题资源化学研究室
作者单位1.Xinjiang Med Univ, Dept Pharmacol, Basic Med Coll, Urumqi 830054, Peoples R China
2.Inst Xinjiang Tradit Uighur Med, Urumqi 830049, Peoples R China
3.Uighur Med Hosp, Urumqi 830049, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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GB/T 7714
Aibai, S ,Anzhaer, A ,Aimaiti, A ,et al. Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients[J]. EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE,2015,7(6):653-656.
APA Aibai, S ,Anzhaer, A ,Aimaiti, A ,Islama, R ,Aimaiti, G ,&Abuduaini, A .(2015).Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients.EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE,7(6),653-656.
MLA Aibai, S ,et al."Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients".EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 7.6(2015):653-656.
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