XJIPC OpenIR  > 资源化学研究室
Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients
Aibai, S (Aibai, Silafu); Anzhaer, A (Anzhaer, Aikebaier); Aimaiti, A (Aimaiti, Ayinuer); Islama, R (Islama, Rabigul); Aimaiti, G (Aimaiti, Gulisitan); Abuduaini, A (Abuduaini, Abudujilili)
2015
Source PublicationEUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
Volume7Issue:6Pages:653-656
Abstract

Introduction: Traditional Uighur medicine humoral (Hilit) theory recognises six different syndrome types of vitiligo. Levels of cytokines, hormones and neurotransmitters relevant to vitiligo were measured in patients diagnosed according to Uighur medicine criteria, in order to identify any association between biochemical parameters and the six syndromes identified by traditional differential diagnosis. Methods: Using ELISA, interferon-gamma (IFN-gamma), soluble intercellular adhesion molecule 1 (sICAM-1), tyrosine enzyme antibody IgG (IgG), 5-hydroxytryptamine (5-HT), cortisol and norepinephrine (NE) levels were measured in peripheral blood serum of 90 healthy adults, and in serum and skin lesional tissue fluid of 450 vitiligo patients. Large sample multi-angle correlation analysis was used to compare data between patients and non-vitiligo suffers and between patients in the six vitiligo syndrome groups. Results: Analysis of biochemical parameters showed that serum levels of sICAM-1, IgG and especially IFNgamma, were higher in patients than in controls, whereas cortisol levels were lower (IFN-gamma, P = 0.017; sICAM-1, P = 0.000; IgG, P = 0.025; cortisol, P = 0.000). IFN-gamma, cortisol, IgG and NE levels were lower in serum than in skin lesional tissue fluid, whereas 5-HT was higher in serum (IFN-gamma, P = 0.000; cortisol, P = 0.000; IgG, P = 0.034; NE, P = 0.000; 5-HT, P = 0.000). There were no differences in serum indicators between syndromes but in skin lesional tissue fluid, IFN-gamma, 5-HT and IgG levels showed significant differences between types, Conclusion: Increased levels of IFN-gamma are associated with the development of vitiligo. The traditional Uighur dialectical typing of vitiligo into six different syndromes is supported by changes in levels of cytokines in skin lesional tissue fluid, but not serum.

KeywordVitiligo Cytokine Ifn-gamma Sicam-1 Igg Cortisol 5-hydroxytryptamine And Norepinephrine Uighur Medicine
DOI10.1016/j.eujim.2015.10.010
Indexed BySCI
WOS IDWOS:000366909200015
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5129
Collection资源化学研究室
Affiliation1.Xinjiang Med Univ, Dept Pharmacol, Basic Med Coll, Urumqi 830054, Peoples R China
2.Inst Xinjiang Tradit Uighur Med, Urumqi 830049, Peoples R China
3.Uighur Med Hosp, Urumqi 830049, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Aibai, S ,Anzhaer, A ,Aimaiti, A ,et al. Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients[J]. EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE,2015,7(6):653-656.
APA Aibai, S ,Anzhaer, A ,Aimaiti, A ,Islama, R ,Aimaiti, G ,&Abuduaini, A .(2015).Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients.EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE,7(6),653-656.
MLA Aibai, S ,et al."Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients".EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE 7.6(2015):653-656.
Files in This Item:
File Name/Size DocType Version Access License
Association analysis(235KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Aibai, S (Aibai, Silafu)]'s Articles
[Anzhaer, A (Anzhaer, Aikebaier)]'s Articles
[Aimaiti, A (Aimaiti, Ayinuer)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Aibai, S (Aibai, Silafu)]'s Articles
[Anzhaer, A (Anzhaer, Aikebaier)]'s Articles
[Aimaiti, A (Aimaiti, Ayinuer)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Aibai, S (Aibai, Silafu)]'s Articles
[Anzhaer, A (Anzhaer, Aikebaier)]'s Articles
[Aimaiti, A (Aimaiti, Ayinuer)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Association analysis of traditional Uighur medicine differential syndrome typing with biochemical parameters in serum and lesional tissue fluid of vitiligo patients.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.