Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo
Talat, Z (Talat, Zulfiye); Tursun, X (Tursun, Xirali); Cheng, LF (Cheng, Lufeng); Mijiti, A (Mijiti, Ailati); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2015
发表期刊PHYTOTHERAPY RESEARCH
卷号29期号:12页码:1901-1909
摘要

Kursi Caper (KC) is a Uighur medicine based on caper which is widely used to treat arthritis and rheumatism, and preliminary studies in our laboratory showed that this traditional formula may possess potent antiinflammatory effects. This study confirms the antiinflammatory effect of KC in the adjuvant induced arthritis (AIA) model, the carrageenan and cotton-pellet induced granuloma rat models, and further investigates in vivo the mechanism of action by measuring relevant indicators of anti-arthritic activity. KC showed significant and dose-dependent anti-arthritic and antiinflammatory effects, demonstrated by reduced paw edema and arthritic scores in all animal models. Histopathological examination showed that KC reduced levels of synovial inflammatory factors in AIA rats. The overproduction of TNF-alpha and IL-1 beta was attenuated, and CAT, MDA and SOD levels were restored to normal in KC-treated rats. KC also significantly reduced LPS-induced proliferation of B lymphocytes and ConA induced proliferation of T lymphocytes in a dose-dependent manner. Flow cytometry showed that the high dose KC-treated group had a significantly decreased frequency of Th17 cells. This study indicates that KC can significantly attenuate arthritis and inflammation in rats by decreasing the levels of inflammatory cytokines, regulating oxidative stress, reducing lymphocyte proliferation and decreasing Th17. This supports the traditional use of KC as a potential modern therapeutic agent for the treatment of arthritis and related conditions.

关键词Kursi Caper Arthritis Inflammation Uighur Traditional Medicine Asia
DOI10.1002/ptr.5479
收录类别SCI
WOS记录号WOS:000367905400007
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5127
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Xinjiang Med Univ, Urumqi 830011, Peoples R China
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Talat, Z ,Tursun, X ,Cheng, LF ,et al. Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo[J]. PHYTOTHERAPY RESEARCH,2015,29(12):1901-1909.
APA Talat, Z ,Tursun, X ,Cheng, LF ,Mijiti, A ,Aisa, HA ,&Aisa, HA.(2015).Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo.PHYTOTHERAPY RESEARCH,29(12),1901-1909.
MLA Talat, Z ,et al."Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo".PHYTOTHERAPY RESEARCH 29.12(2015):1901-1909.
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