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Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo
Talat, Z (Talat, Zulfiye); Tursun, X (Tursun, Xirali); Cheng, LF (Cheng, Lufeng); Mijiti, A (Mijiti, Ailati); Aisa, HA (Aisa, Haji Akber)
2015
Source PublicationPHYTOTHERAPY RESEARCH
ISSN0951-418X
Volume29Issue:12Pages:1901-1909
Abstract

Kursi Caper (KC) is a Uighur medicine based on caper which is widely used to treat arthritis and rheumatism, and preliminary studies in our laboratory showed that this traditional formula may possess potent antiinflammatory effects. This study confirms the antiinflammatory effect of KC in the adjuvant induced arthritis (AIA) model, the carrageenan and cotton-pellet induced granuloma rat models, and further investigates in vivo the mechanism of action by measuring relevant indicators of anti-arthritic activity. KC showed significant and dose-dependent anti-arthritic and antiinflammatory effects, demonstrated by reduced paw edema and arthritic scores in all animal models. Histopathological examination showed that KC reduced levels of synovial inflammatory factors in AIA rats. The overproduction of TNF-alpha and IL-1 beta was attenuated, and CAT, MDA and SOD levels were restored to normal in KC-treated rats. KC also significantly reduced LPS-induced proliferation of B lymphocytes and ConA induced proliferation of T lymphocytes in a dose-dependent manner. Flow cytometry showed that the high dose KC-treated group had a significantly decreased frequency of Th17 cells. This study indicates that KC can significantly attenuate arthritis and inflammation in rats by decreasing the levels of inflammatory cytokines, regulating oxidative stress, reducing lymphocyte proliferation and decreasing Th17. This supports the traditional use of KC as a potential modern therapeutic agent for the treatment of arthritis and related conditions.

KeywordKursi Caper Arthritis Inflammation Uighur Traditional Medicine Asia
DOI10.1002/ptr.5479
Indexed BySCI
WOS IDWOS:000367905400007
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5127
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Xinjiang Med Univ, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Talat, Z ,Tursun, X ,Cheng, LF ,et al. Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo[J]. PHYTOTHERAPY RESEARCH,2015,29(12):1901-1909.
APA Talat, Z ,Tursun, X ,Cheng, LF ,Mijiti, A ,&Aisa, HA .(2015).Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo.PHYTOTHERAPY RESEARCH,29(12),1901-1909.
MLA Talat, Z ,et al."Anti-Arthritic and Antiinflammatory Effects of the Traditional Uighur Formula Kursi Caper In Vivo".PHYTOTHERAPY RESEARCH 29.12(2015):1901-1909.
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