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Alkaloid constituents from Viola tianschanica
Chen, QB (Chen, Qi-Bin); Aisa, HA (Aisa, Haji Akber); Aisa, HA
Source PublicationPHYTOCHEMISTRY

Eighteen previously undescribed alkaloids, tishaviolamines A-J, including eight pairs of enantiomers, together with two known benzylisoquinoline alkaloids, (-)-bicuculline and (-)-corlumine, were isolated from Viola tianschanica. Among them, tishaviolamine A-E were demonstrated to possess three types of unpresented skeletons. The structures of these alkaloids were established by comprehensive analyses of the 1D, 2D-NMR and (+)HRESIMS data. The absolute configurations of enantiomers were determined by comparing their calculated ECD spectra with the experimental ones. The menin-mixed lineage leukemia 1 protein-protein interaction inhibitory effect of the isolated compounds were also measured.

KeywordViola Tianshanica Violaceae Alkaloids Menin-mll1 Protein-protein Interaction Inhibitory Effect
Indexed BySCI
WOS IDWOS:000418628100026
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorAisa, HA
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Chen, QB ,Aisa, HA ,Aisa, HA. Alkaloid constituents from Viola tianschanica[J]. PHYTOCHEMISTRY,2017,144(12):233-242.
APA Chen, QB ,Aisa, HA ,&Aisa, HA.(2017).Alkaloid constituents from Viola tianschanica.PHYTOCHEMISTRY,144(12),233-242.
MLA Chen, QB ,et al."Alkaloid constituents from Viola tianschanica".PHYTOCHEMISTRY 144.12(2017):233-242.
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