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An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3/-Catenin Signaling Pathways
Yin, L (Yin, Li); Niu, C (Niu, Chao); Liao, LX (Liao, Li-xin); Dou, J (Dou, Jun); Habasi, M (Habasi, Maidina); Aisa, HA (Aisa, Haji Akber)
2017
Source PublicationMOLECULES
ISSN1420-3049
Volume22Issue:12Pages:1-12
Abstract

Plants or plant-derived products have been routinely used in several traditional medicine systems for vitiligo treatment. It is well-known that melanogenesis can be promoted by certain flavonoid compounds isolated from the traditional Uyghur medicinal plant, Kaliziri. Therefore, Chalcones, one class of flavonoid compounds, has become an interesting target for the development of anti-vitiligo agents. A series of novel isoxazole chalcone derivatives have been designed, synthesized, and evaluated for biological activities by our group. Among them, derivative 1-(4-((3-phenylisoxazol-5-yl)methoxy)phenyl)-3-phenylprop-2-en-1-one (PMPP) was identified as a potent tyrosinase activator with better activity and lower toxicity than the positive control 8-methoxypsoralen (8-MOP) in this study. Further investigations revealed that Akt and GSK3 were the signaling pathways involved in the hyperpigmentation of PMPP. Overall, these studies may provide a convenient and novel approach for the further development of anti-vitiligo agents.

KeywordChalcone Derivative Pi3k Akt Wnt -catenin Melanogenesis B16 Melanoma
DOI10.3390/molecules22122077
Indexed BySCI
WOS IDWOS:000419242400047
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5117
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China
2.Xinjiang Inst Engn, Dept Chem Engn, Urumqi 830091, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Yin, L ,Niu, C ,Liao, LX ,et al. An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3/-Catenin Signaling Pathways[J]. MOLECULES,2017,22(12):1-12.
APA Yin, L ,Niu, C ,Liao, LX ,Dou, J ,Habasi, M ,&Aisa, HA .(2017).An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3/-Catenin Signaling Pathways.MOLECULES,22(12),1-12.
MLA Yin, L ,et al."An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3/-Catenin Signaling Pathways".MOLECULES 22.12(2017):1-12.
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