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Improvement of imprinting effect of ionic liquid molecularly imprinted polymers by use of a molecular crowding agent
Jia, M (Jia, Man); Yang, J (Yang, Jian); Sun, YK (Sun, Ya Kun); Bai, X (Bai, Xi); Wu, T (Wu, Tao); Liu, ZS (Liu, Zhao Sheng); Aisa, HA (Aisa, Haji Akber)
2018
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume410Issue:2Pages:595-604
Abstract

We aimed to improve the imprinting effect of ionic liquid molecularly imprinted polymers (MIPs) by use of a molecular crowding agent. The ionic liquid 1-vinyl-3-ethylimidazolium tetrafluoroborate ([VEIm][BF4]) was used as the functional monomer and aesculetin was used as the template molecule in a crowding environment, which was made up of a tetrahydrofuran solution of polystyrene. The ionic liquid MIPs that were prepared in the crowding environment displayed an enhanced imprinting effect. NMR peak shifts of active hydrogen of aesculetin suggested that interaction between the functional monomer and the template could be increased by the use of a crowding agent in the self-assembly process. The retention and selectivity of aesculetin were affected greatly by high molecular crowding, the amount of high molecular weight crowding agent, and the ratio of [VEIm][BF4] to aesculetin. The optimal MIPs were used as solid-phase extraction sorbents to extract aesculetin from Cichorium glandulosum. A calibration curve was obtained with aesculetin concentrations from 0.0005 to 0.05 mg mL(-1) (correlation coefficient R (2) of 0.9999, y = 1519x + 0.0923). The limit of quantification was 0.12 mu g mL(-1), and the limit of detection was 0.05 mu g mL(-1). The absolute recovery of aesculetin was (80 +/- 2)% (n = 3), and the purity of aesculetin was (92 +/- 0.5)% (n = 5). As a conclusion, molecular crowding is an effective approach to obtain ionic liquid MIPs with high selectivity even in a polar solvent environment.

KeywordMolecular Crowding Agent Ionic Liquid Monomer Aesculetin Solid-phase Extraction Molecularly Imprinted Polymer
DOI10.1007/s00216-017-0760-5
Indexed BySCI
WOS IDWOS:000419127900028
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5116
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Jia, M ,Yang, J ,Sun, YK ,et al. Improvement of imprinting effect of ionic liquid molecularly imprinted polymers by use of a molecular crowding agent[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2018,410(2):595-604.
APA Jia, M .,Yang, J .,Sun, YK .,Bai, X .,Wu, T .,...&Aisa, HA .(2018).Improvement of imprinting effect of ionic liquid molecularly imprinted polymers by use of a molecular crowding agent.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,410(2),595-604.
MLA Jia, M ,et al."Improvement of imprinting effect of ionic liquid molecularly imprinted polymers by use of a molecular crowding agent".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 410.2(2018):595-604.
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