Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits
Tohtahon, Z (Tohtahon, Zeynep); Zhang, L (Zhang, Lu); Han, JX (Han, Jianxin); Xie, X (Xie, Xing); Tu, ZC (Tu, Zongcai); Yuan, T (Yuan, Tao); Yuan, T
2017
发表期刊JOURNAL OF FOOD BIOCHEMISTRY
卷号41期号:4
摘要

This research aimed to optimize the extraction condition, and to identify and investigate the bioactivities of triterpenoids from Crataegus cuneata. The optimum extraction conditions for recovering triterpenoids from hawthorn were ultrasound-assisted extraction with 80% methanol at 30 degrees C, 400 W for 20 min, which resulted in the recovery of total triterpenoids of 28.47 mg/g dry material. Further isolation work led to the isolation and identification of six triterpenoids: ursolic acid (1), maslic acid (2), corsolic acid (3), pomolic acid (4), euscaphic acid (5), and 2, 19-dihydroxy-3-oxo-urs-12-en-28-oic acid (6) from the triterpenoid-enriched C. cuneata fruits extracts (TCFE). Among which pomolic acid and euscaphic acid were firstly found in genus Crataegus. Biological evaluation revealed that all of the isolated triterpenoids and TCFE showed considerable xanthine oxidase and tyrosinase inhibitory activities, while some of isolates exhibited considerable acetylcholinesterase inhibitory activities. Practical applicationsTriterpenoids are one class of the major compounds with broad biological activities in hawthorn species. Crataegus cuneata is one of the two major hawthorn species found in China. But, there is few data on the constituents and bioactivity of triterpenoids present in C. cuneata. This research indicated that ultrasound-assisted extraction is the suitable method for extracting triterpenoids from C. cuneata, and TCFE could be potentially used for against xanthine oxidase and tyrosinase-induced diseases, which could provide useful information for the further development of C.cuneata fruits.

关键词Crataegus Cuneata Extraction Optimization Structural Identification Triterpenoids Tyrosinase Xanthine Oxidase
DOI10.1111/jfbc.12377
收录类别SCI
WOS记录号WOS:000407085800006
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5112
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Yuan, T
作者单位1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, State Key Lab Xinjiang Indigenous Med Plants Reso, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
3.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
4.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Nanchang Univ, Coll Food Sci, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
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GB/T 7714
Tohtahon, Z ,Zhang, L ,Han, JX ,et al. Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits[J]. JOURNAL OF FOOD BIOCHEMISTRY,2017,41(4).
APA Tohtahon, Z .,Zhang, L .,Han, JX .,Xie, X .,Tu, ZC .,...&Yuan, T.(2017).Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.JOURNAL OF FOOD BIOCHEMISTRY,41(4).
MLA Tohtahon, Z ,et al."Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits".JOURNAL OF FOOD BIOCHEMISTRY 41.4(2017).
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