XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits
Tohtahon, Z (Tohtahon, Zeynep); Zhang, L (Zhang, Lu); Han, JX (Han, Jianxin); Xie, X (Xie, Xing); Tu, ZC (Tu, Zongcai); Yuan, T (Yuan, Tao); Yuan, T
2017
Source PublicationJOURNAL OF FOOD BIOCHEMISTRY
ISSN0145-8884
Volume41Issue:4Pages:1-9
Abstract

This research aimed to optimize the extraction condition, and to identify and investigate the bioactivities of triterpenoids from Crataegus cuneata. The optimum extraction conditions for recovering triterpenoids from hawthorn were ultrasound-assisted extraction with 80% methanol at 30 degrees C, 400 W for 20 min, which resulted in the recovery of total triterpenoids of 28.47 mg/g dry material. Further isolation work led to the isolation and identification of six triterpenoids: ursolic acid (1), maslic acid (2), corsolic acid (3), pomolic acid (4), euscaphic acid (5), and 2, 19-dihydroxy-3-oxo-urs-12-en-28-oic acid (6) from the triterpenoid-enriched C. cuneata fruits extracts (TCFE). Among which pomolic acid and euscaphic acid were firstly found in genus Crataegus. Biological evaluation revealed that all of the isolated triterpenoids and TCFE showed considerable xanthine oxidase and tyrosinase inhibitory activities, while some of isolates exhibited considerable acetylcholinesterase inhibitory activities. Practical applicationsTriterpenoids are one class of the major compounds with broad biological activities in hawthorn species. Crataegus cuneata is one of the two major hawthorn species found in China. But, there is few data on the constituents and bioactivity of triterpenoids present in C. cuneata. This research indicated that ultrasound-assisted extraction is the suitable method for extracting triterpenoids from C. cuneata, and TCFE could be potentially used for against xanthine oxidase and tyrosinase-induced diseases, which could provide useful information for the further development of C.cuneata fruits.

KeywordCrataegus Cuneata Extraction Optimization Structural Identification Triterpenoids Tyrosinase Xanthine Oxidase
DOI10.1111/jfbc.12377
Indexed BySCI
WOS IDWOS:000407085800006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5112
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorYuan, T
Affiliation1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, State Key Lab Xinjiang Indigenous Med Plants Reso, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
3.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
4.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Nanchang Univ, Coll Food Sci, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
Recommended Citation
GB/T 7714
Tohtahon, Z ,Zhang, L ,Han, JX ,et al. Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits[J]. JOURNAL OF FOOD BIOCHEMISTRY,2017,41(4):1-9.
APA Tohtahon, Z .,Zhang, L .,Han, JX .,Xie, X .,Tu, ZC .,...&Yuan, T.(2017).Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.JOURNAL OF FOOD BIOCHEMISTRY,41(4),1-9.
MLA Tohtahon, Z ,et al."Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits".JOURNAL OF FOOD BIOCHEMISTRY 41.4(2017):1-9.
Files in This Item:
File Name/Size DocType Version Access License
Extraction optimizat(487KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tohtahon, Z (Tohtahon, Zeynep)]'s Articles
[Zhang, L (Zhang, Lu)]'s Articles
[Han, JX (Han, Jianxin)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tohtahon, Z (Tohtahon, Zeynep)]'s Articles
[Zhang, L (Zhang, Lu)]'s Articles
[Han, JX (Han, Jianxin)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tohtahon, Z (Tohtahon, Zeynep)]'s Articles
[Zhang, L (Zhang, Lu)]'s Articles
[Han, JX (Han, Jianxin)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.