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PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E(-/-)mice and Changliver cell[S]
Yan, D (Yan, Dong); Wei, YY (Wei, Yuan-Yuan); Li, XM (Li, Xiu-Mei); Sun, XC (Sun, Xiu-Chao); Wang, Z (Wang, Zhong); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2017
发表期刊AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
卷号9期号:6页码:3073-3083
摘要

High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through the dysregulation of genes involved in lipid metabolism, but the precise mechanism is still unknown. Pomegranate flowers are used to treat diabetes mellitus in traditional Uighur medicine. Here we sought to investigate the effect and mechanism of pomegranate flower polyphenols (PFP) on NAFLD Apo E(-/-)mice induced by a high-fat diet (HFD) and whether PFP improves NAFLD through decreasing oxidative stress. PFP supplementation in mice significantly reduced the HFD-induced gains in body weight compared with the mice fed only with HFD. It also significantly reduced HFD-induced increases in serum lipids, including cholesterol and triglyceride. Consistent with the reduced liver weight, hepatic lipid accumulation, and the size of lipid droplets in the epididymal fat pads were also reduced by PFP supplementation. To further investigate how PFP may reduce obesity, we analyzed lipid metabolism-related genes in the liver. PFP supplementation altered expression profiles of several lipid metabolism-related genes, including ACC, AMPK, CPT-1 alpha, FAS, LDLR, Leptin, LXR, PON1, PPAR, SirT3, and SREBP, relative to those in HFD control mice. The expression patterns of these genes observed by quantitative reverse transcriptase-polymerase chain reaction and AMPK, SirT3, ACC2, and CPT-1A expression were confirmed by immunohistochemical assays. Collectively, our results indicate that PFP prevents HFD-induced obesity in Apo E-/-mice, and its anti-obesity effects may be related to the regulation of lipogenesis at the level of transcription.

关键词Pfp (Pomegranate Flower Polyphone) Nonalcoholic Fatty Liver Disease Apo E-/- Mice
收录类别SCI
WOS记录号WOS:000404548300035
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5093
专题资源化学研究室
通讯作者Aisa, HA
作者单位Xinjiang Med Univ, Dept Pharmacol, Urumqi, Peoples R China;Xinjiang Med Univ, Dept Physiol, Urumqi, Peoples R China;Xinjiang Med Univ, Morphol Ctr, Urumqi, Peoples R China;Xinjiang Med Univ, Anim Ctr, Urumqi, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
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Yan, D ,Wei, YY ,Li, XM ,et al. PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E(-/-)mice and Changliver cell[S][J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2017,9(6):3073-3083.
APA Yan, D .,Wei, YY .,Li, XM .,Sun, XC .,Wang, Z .,...&Aisa, HA.(2017).PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E(-/-)mice and Changliver cell[S].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,9(6),3073-3083.
MLA Yan, D ,et al."PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E(-/-)mice and Changliver cell[S]".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 9.6(2017):3073-3083.
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