Two new triterpenes from Euphorbia alatavica
Rozimama, R (Rozimama, Rushangul); Kehrimen, N (Kehrimen, Nurmuhammat); Gao, J (Gao, Jie); Ma, HR (Ma, Hai-Rong); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2017
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷号19期号:10页码:966-973
摘要

A phytochemical investigation on Euphorbia alatavica Boiss resulted in the isolation of nine compounds, including two new ones, alatavolide and alatavoic acid (1-2). Chemical structures of these compounds were established on the basis of 1D, 2D NMR, and HR-MS techniques, and by comparison with data reported in the literature. Compounds 1, 2, 4, 6, 8, and 9 were screened for cytotoxicity using the MTT assay. Among these compounds, the new compound 2 showed moderate cytotoxicity against Hela, MCF-7 and A549 cell lines (IC50 values of 16.4 +/- 3.2, 14.5 +/- 2.8, 22.3 +/- 3.1 mu M, respectively), while the known compound 8 exhibited the most potent cytotoxicity with the IC50 values of 6.5 +/- 3.1, 1.9 +/- 0.9, 8.6 +/- 3.5 mu M, respectively.

关键词Euphorbia Alatavica Triterpene Bioactivity
DOI10.1080/10286020.2017.1307835
收录类别SCI
WOS记录号WOS:000413701800004
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5087
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
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GB/T 7714
Rozimama, R ,Kehrimen, N ,Gao, J ,et al. Two new triterpenes from Euphorbia alatavica[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2017,19(10):966-973.
APA Rozimama, R ,Kehrimen, N ,Gao, J ,Ma, HR ,Aisa, HA ,&Aisa, HA.(2017).Two new triterpenes from Euphorbia alatavica.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,19(10),966-973.
MLA Rozimama, R ,et al."Two new triterpenes from Euphorbia alatavica".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 19.10(2017):966-973.
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