XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo
Niu, C (Niu, Chao); Aisa, HA (Aisa, Haji A.)
2017
Source PublicationMOLECULES
ISSN1420-3049
Volume22Issue:8Pages:1-28
Abstract

Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents.

KeywordMelanogenesis Tyrosinase Activity Vitiligo Plant Extracts Natural Products Synthesized Derivatives Analogues
DOI10.3390/molecules22081303
Indexed BySCI
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Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5047
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji A.)
Affiliation1.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Niu, C ,Aisa, HA . Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo[J]. MOLECULES,2017,22(8):1-28.
APA Niu, C ,&Aisa, HA .(2017).Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.MOLECULES,22(8),1-28.
MLA Niu, C ,et al."Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo".MOLECULES 22.8(2017):1-28.
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