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Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities
Turak, A (Turak, Ablajan); Maimaiti, Z (Maimaiti, Zulipiya); Ma, HR (Ma, HaiRong); Aisa, HA (Aisa, Haji Akber)
2017
Source PublicationPHYTOCHEMISTRY LETTERS
ISSN1874-3900
Volume21Issue:9Pages:163-168
Abstract

Three new pseudo-disesquiterpenoids, vernodalidimer F - H (1 - 3), which are formed by esterification of two sesquiterpenoids, along with a new sesquiterpenoid (4) and two known sesquiterpeonids (5, 6) were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by NMR data. The absolute configurations of 1-3 and 5 were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolated compounds against four human tumor cell lines were assayed. 5 exhibited strong cytotoxicity against HCT-15, PC-3, A549 and Hela cells lines with IC50 values of 5.3, 5.6, 6.2, and 8.2 mu M, respectively. 2 showed non-concentration dependent cytotoxicity against HCT-15, PC-3, and A549 cells lines with inhibition rate of 56.1%, 55.3%, and 50.1%, respectively. 1 and 3 showed moderate cytotoxicity against four cell lines with IC50 values ranging from 12.2 +/- 5.1 to 28.6 +/- 2.5 mu M. The influence of melanin content in B16 melanoma cells of 1, 5, and 6 were tested, and they increased melanin content by 43.6%, 28.1%, and 37.0% higher than positive control 8-methoxypsoralen.

KeywordVernonia Anthelmintica Pseudo-disesquiterpenoid Sesquiterpenoids Ecd Cytotoxicity Melanin Content
DOI10.1016/j.phytol.2017.06.017
Indexed BySCI
WOS IDWOS:000414229300032
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5040
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Turak, A ,Maimaiti, Z ,Ma, HR ,et al. Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities[J]. PHYTOCHEMISTRY LETTERS,2017,21(9):163-168.
APA Turak, A ,Maimaiti, Z ,Ma, HR ,&Aisa, HA .(2017).Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities.PHYTOCHEMISTRY LETTERS,21(9),163-168.
MLA Turak, A ,et al."Pseudo-disesquiterpenoids from seeds of Vernonia anthelmintica and their biological activities".PHYTOCHEMISTRY LETTERS 21.9(2017):163-168.
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