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Isochlorogenic acid A promotes melanin synthesis in B16 cell through the beta-catenin signal pathway
Mamat, N (Mamat, Nuramina); Dou, J (Dou, Jun); Lu, XY (Lu, Xueying); Eblimit, A (Eblimit, Aiden); Akber, AH (Akber, Aisa Haji)
2017
Source PublicationACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN1672-9145
Volume49Issue:9Pages:800-807
Abstract

Isochlorogenic acid A, also called 3,5-dicaffeoylquinic acid (3,5-diCQA), is a widespread phenolic compound in the plant. Recent studies have shown that it has antioxidant and anti-inflammatory activity. In addition, oxidative stress and inflammation induced by solar ultraviolet radiation is a very significant reason for skin depigmentation. Therefore, in this study, we evaluated the effect of 3,5-diCQA on B16 cells and explored its molecular mechanism. Results showed that 3,5-diCQA upregulated intracellular melanin production in a time-and dose-dependent manner. Tyrosinase (TYR) activity was also increased after treatment with 3,5-diCQA in a dose-dependent manner. Expressions of TYR, TYR-related protein1, TYR-related protein2, and microphthalmia-associated transcription factor were upregulated in a dose-dependent manner after 48 h of treatment with 3,5-diCQA. Results also showed that 3,5-diCQA promoted the phosphorylation of Akt at Thr308 and glycogen synthase kinase-3 beta at Ser 9. Moreover, 3,5-diCQA increased the content of beta-catenin in cell cytoplasm and nucleus by reducing the content of phosphorylated beta-catenin (p-beta-catenin). All these results suggest that 3,5-diCQA may mediate the acceleration of melanin synthesis by the beta-catenin signal pathway.

KeywordIsochlorogenic Acid a Melanogenesis Beta-catenin Beta-catenin Signal Pathway
DOI10.1093/abbs/gmx072
Indexed BySCI
WOS IDWOS:000409246700006
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5038
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorAkber, AH (Akber, Aisa Haji)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA
Recommended Citation
GB/T 7714
Mamat, N ,Dou, J ,Lu, XY ,et al. Isochlorogenic acid A promotes melanin synthesis in B16 cell through the beta-catenin signal pathway[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2017,49(9):800-807.
APA Mamat, N ,Dou, J ,Lu, XY ,Eblimit, A ,&Akber, AH .(2017).Isochlorogenic acid A promotes melanin synthesis in B16 cell through the beta-catenin signal pathway.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,49(9),800-807.
MLA Mamat, N ,et al."Isochlorogenic acid A promotes melanin synthesis in B16 cell through the beta-catenin signal pathway".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 49.9(2017):800-807.
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