Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus
Tohtahon, Z (Tohtahon, Zeynep);   Xue, JJ (Xue, JingJing);   Han, JX (Han, Jianxin);   Liu, YS (Liu, Yushuang);   Hua, HM (Hua, Huiming);   Yuan, T (Yuan, Tao); Yuan, T
2017
发表期刊PHYTOCHEMISTRY
卷号143期号:11页码:98-103
摘要

Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC50 = 1.77 mu M) and human acute monocytic leukemia cell line THP-1 (IC50 = 8.21 mu M) to those of positive control, fluorouracil (IC50 = 6.38 and 4.41 mu M, respectively).

关键词Piptoporus Betulinus Polyporaceae Lanostane Triterpenoid Cytotoxicity Hl-60
DOI10.1016/j.phytochem.2017.07.013
收录类别SCI
WOS记录号WOS:000413128900012
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5024
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Yuan, T
作者单位Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China;Univ Chinese Acad Sci, Beijing 100049, Peoples R China;Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
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Tohtahon, Z ,Yuan, T. Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus[J]. PHYTOCHEMISTRY,2017,143(11):98-103.
APA Tohtahon, Z ,&Yuan, T.(2017).Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.PHYTOCHEMISTRY,143(11),98-103.
MLA Tohtahon, Z ,et al."Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus".PHYTOCHEMISTRY 143.11(2017):98-103.
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