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Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus
Tohtahon, Z (Tohtahon, Zeynep)[ 1,2,3 ]; Xue, JJ (Xue, JingJing)[ 4 ]; Han, JX (Han, Jianxin)[ 1,2,3 ]; Liu, YS (Liu, Yushuang)[ 1,2,3 ]; Hua, HM (Hua, Huiming)[ 4 ]; Yuan, T (Yuan, Tao)[ 1,2 ]
2017
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume143Issue:11Pages:98-103
Abstract

Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC50 = 1.77 mu M) and human acute monocytic leukemia cell line THP-1 (IC50 = 8.21 mu M) to those of positive control, fluorouracil (IC50 = 6.38 and 4.41 mu M, respectively).

KeywordPiptoporus Betulinus Polyporaceae Lanostane Triterpenoid Cytotoxicity Hl-60
DOI10.1016/j.phytochem.2017.07.013
Indexed BySCI
WOS IDWOS:000413128900012
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5024
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorXue, JJ (Xue, JingJing)[ 4 ]
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Tohtahon, Z ,Xue, JJ ,Han, JX ,et al. Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus[J]. PHYTOCHEMISTRY,2017,143(11):98-103.
APA Tohtahon, Z ,Xue, JJ ,Han, JX ,Liu, YS ,Hua, HM ,&Yuan, T .(2017).Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.PHYTOCHEMISTRY,143(11),98-103.
MLA Tohtahon, Z ,et al."Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus".PHYTOCHEMISTRY 143.11(2017):98-103.
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