Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus
Tohtahon, Z (Tohtahon, Zeynep)[ 1,2,3 ]; Xue, JJ (Xue, JingJing)[ 4 ]; Han, JX (Han, Jianxin)[ 1,2,3 ]; Liu, YS (Liu, Yushuang)[ 1,2,3 ]; Hua, HM (Hua, Huiming)[ 4 ]; Yuan, T (Yuan, Tao)[ 1,2 ]
2017
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号143期号:11页码:98-103
摘要

Chemical investigation of a bioactive methanolic extract of the fruiting bodies of Piptoporus betulinus led to the isolation of five previously undescribed lanostane triterpenoids named piptolinic acids A-E, as well as five known lanostane triterpenoids. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic and HRESIMS analysis. Piptolinic acid A with an unusual moiety (3-hydroxy-4methoxycarbonyl-3-methylbutyryloxy) at C-3 exhibited comparable cytotoxic activity against human promyelocytic leukemia cell line HL-60 (IC50 = 1.77 mu M) and human acute monocytic leukemia cell line THP-1 (IC50 = 8.21 mu M) to those of positive control, fluorouracil (IC50 = 6.38 and 4.41 mu M, respectively).

关键词Piptoporus Betulinus Polyporaceae Lanostane Triterpenoid Cytotoxicity Hl-60
DOI10.1016/j.phytochem.2017.07.013
收录类别SCI
WOS记录号WOS:000413128900012
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5024
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Xue, JJ (Xue, JingJing)[ 4 ]
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Xinjiang Indigenous Med Plants Reso, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Tohtahon, Z ,Xue, JJ ,Han, JX ,et al. Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus[J]. PHYTOCHEMISTRY,2017,143(11):98-103.
APA Tohtahon, Z ,Xue, JJ ,Han, JX ,Liu, YS ,Hua, HM ,&Yuan, T .(2017).Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.PHYTOCHEMISTRY,143(11),98-103.
MLA Tohtahon, Z ,et al."Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus".PHYTOCHEMISTRY 143.11(2017):98-103.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Cytotoxic lanostane (666KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tohtahon, Z (Tohtahon, Zeynep)[ 1,2,3 ]]的文章
[Xue, JJ (Xue, JingJing)[ 4 ]]的文章
[Han, JX (Han, Jianxin)[ 1,2,3 ]]的文章
百度学术
百度学术中相似的文章
[Tohtahon, Z (Tohtahon, Zeynep)[ 1,2,3 ]]的文章
[Xue, JJ (Xue, JingJing)[ 4 ]]的文章
[Han, JX (Han, Jianxin)[ 1,2,3 ]]的文章
必应学术
必应学术中相似的文章
[Tohtahon, Z (Tohtahon, Zeynep)[ 1,2,3 ]]的文章
[Xue, JJ (Xue, JingJing)[ 4 ]]的文章
[Han, JX (Han, Jianxin)[ 1,2,3 ]]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Cytotoxic lanostane triterpenoids from the fruiting bodies of Piptoporus betulinus.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。