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Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
Yuan, WJ (Yuan, Wen-Juan)[ 1,2,3 ]; Ding, X (Ding, Xiao)[ 1 ]; Wang, Z (Wang, Zhe)[ 1 ]; Yang, BJ (Yang, Bi-Juan)[ 1 ]; Li, XN (Li, Xiao-Nian)[ 1 ]; Zhang, Y (Zhang, Yu)[ 1 ]; Chen, DZ (Chen, Duo-Zhi)[ 1 ]; Li, SL (Li, Shun-Lin)[ 1 ]; Chen, Q (Chen, Quan)[ 4 ]; Di, YT (Di, Ying-Tong)[ 1 ]; Aisa, HA (Aisa, Haji Akber)[ 2 ]; Hao, XJ (Hao, Xiao-Jiang)[ 1 ]
2017
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7Issue:11Pages:1-9
Abstract

Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC50 values of 2.61 and 4.08 mu M, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC50 values of 16.48 and 34.76 mu M, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells.

DOI10.1038/s41598-017-14637-w
Indexed BySCI
WOS IDWOS:000414415000007
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/5022
Collection资源化学研究室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yuan, WJ ,Ding, X ,Wang, Z ,et al. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A[J]. SCIENTIFIC REPORTS,2017,7(11):1-9.
APA Yuan, WJ .,Ding, X .,Wang, Z .,Yang, BJ .,Li, XN .,...&Hao, XJ .(2017).Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A.SCIENTIFIC REPORTS,7(11),1-9.
MLA Yuan, WJ ,et al."Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A".SCIENTIFIC REPORTS 7.11(2017):1-9.
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