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Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
Yuan, WJ (Yuan, Wen-Juan);   Ding, X (Ding, Xiao);   Wang, Z (Wang, Zhe);   Yang, BJ (Yang, Bi-Juan);   Li, XN (Li, Xiao-Nian);   Chen, Q (Chen, Quan);   Di, YT (Di, Ying-Tong);   Aisa, HA (Aisa, Haji Akber);   Hao, XJ (Hao, Xiao-Jiang)
2017
发表期刊SCIENTIFIC REPORTS
卷号7期号:11
摘要

Rare ent-abietane-rosane diterpenoid heterodimers, Bisebracteolasins A and B (1 and 2, respectively), were isolated from the roots of Euphorbia ebracteolata Hayata. Their structures and absolute configurations were elucidated from spectroscopic data and X-ray diffraction analysis. Compounds 1 and 2 exhibited moderate cytotoxic effects against five cancer cell lines. Compound 1 showed more effective antiproliferative activities against human tumour cells, HL-60 and SMMC-7721, with IC50 values of 2.61 and 4.08 mu M, respectively, than 2. Both compounds 1 and 2 inhibit the colorectal cancer stem cell line P6C with IC50 values of 16.48 and 34.76 mu M, respectively. Moreover, preliminary biological tests showed compound 1 exhibited inhibitory activity towards tumoursphere formation and migration of the P6C cell line. Overall, we identified two novel diterpenoid heterodimers, and Bisebracteolasin A exhibits therapeutic potential in impeding tumour growth and metastatic ability of cancer stem cells.

DOI10.1038/s41598-017-14637-w
收录类别SCI
WOS记录号WOS:000414415000007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/5022
专题资源化学研究室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China;Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Xinjiang, Peoples R China;Univ Chinese Acad Sci, Beijing 100049, Peoples R China;Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
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Yuan, WJ . Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A[J]. SCIENTIFIC REPORTS,2017,7(11).
APA Yuan, WJ .(2017).Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A.SCIENTIFIC REPORTS,7(11).
MLA Yuan, WJ ."Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A".SCIENTIFIC REPORTS 7.11(2017).
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