XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith
Sun, GY (Sun, Guang-Ying); Zhong, DD (Zhong, Dan-Dan); Li, XJ (Li, Xiang-Jie); Luo, YQ (Luo, Yu-Qing); Ba, H (Ba, Hang); Liu, ZS (Liu, Zhao-Sheng); Aisa, HA (Aisa, Haji Akber)
2015
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume407Issue:24Pages:7401-7412
Abstract

One of the main challenges in the preparation of molecularly imprinted polymers (MIPs) is the substantial initial amount of template needed because of the requirement of high load capacities for most applications. A new strategy of macromolecular crowding was suggested to solve this problem by reducing the amount of template in the polymerization recipe. In a ternary porogenic system of polystyrene (PS) (crowding agent), tetrahydrofuran, and toluene, an imprinted monolithic column with high porosity and good permeability was synthesized using a mixture of ellagic acid (template), acrylamide, and ethylene glycol dimethacrylate. The effect of polymerization factors, including monomer-template molar ratio and the molecular weight and concentration of PS, on the imprinting effect of the resulting MIP monoliths was systematically investigated. At a high ratio of monomer-template (120:1), the greatest imprinting factor of 32.4 was obtained on the MIP monolith with the aid of macromolecular crowding agent. The PS-based imprinted monolith had imprinting even at the extremely high ratio of functional monomer to template of 1510:1. Furthermore, an off-line solid-phase extraction based on the ground MIP was conducted, and the purification recovery of ellagic acid from pomegranate-rind extract was up to 80 %. In conclusion, this approach based on macromolecular crowding is simple, and is especially valuable for those applications of MIP preparation for which a rare template is used.

KeywordMonolith Molecularly Imprinted Polymer Polystyrene Ellagic Acid Macromolecular Crowding Agent
DOI10.1007/s00216-015-8902-0
Indexed BySCI
WOS IDWOS:000361396300015
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4865
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
Recommended Citation
GB/T 7714
Sun, GY ,Zhong, DD ,Li, XJ ,et al. Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(24):7401-7412.
APA Sun, GY .,Zhong, DD .,Li, XJ .,Luo, YQ .,Ba, H .,...&Aisa, HA .(2015).Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(24),7401-7412.
MLA Sun, GY ,et al."Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.24(2015):7401-7412.
Files in This Item:
File Name/Size DocType Version Access License
Effect of minimizing(1329KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, GY (Sun, Guang-Ying)]'s Articles
[Zhong, DD (Zhong, Dan-Dan)]'s Articles
[Li, XJ (Li, Xiang-Jie)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, GY (Sun, Guang-Ying)]'s Articles
[Zhong, DD (Zhong, Dan-Dan)]'s Articles
[Li, XJ (Li, Xiang-Jie)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, GY (Sun, Guang-Ying)]'s Articles
[Zhong, DD (Zhong, Dan-Dan)]'s Articles
[Li, XJ (Li, Xiang-Jie)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.