Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith
Sun, GY (Sun, Guang-Ying); Zhong, DD (Zhong, Dan-Dan); Li, XJ (Li, Xiang-Jie); Luo, YQ (Luo, Yu-Qing); Ba, H (Ba, Hang); Liu, ZS (Liu, Zhao-Sheng); Aisa, HA (Aisa, Haji Akber)
2015
发表期刊ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷号407期号:24页码:7401-7412
摘要One of the main challenges in the preparation of molecularly imprinted polymers (MIPs) is the substantial initial amount of template needed because of the requirement of high load capacities for most applications. A new strategy of macromolecular crowding was suggested to solve this problem by reducing the amount of template in the polymerization recipe. In a ternary porogenic system of polystyrene (PS) (crowding agent), tetrahydrofuran, and toluene, an imprinted monolithic column with high porosity and good permeability was synthesized using a mixture of ellagic acid (template), acrylamide, and ethylene glycol dimethacrylate. The effect of polymerization factors, including monomer-template molar ratio and the molecular weight and concentration of PS, on the imprinting effect of the resulting MIP monoliths was systematically investigated. At a high ratio of monomer-template (120:1), the greatest imprinting factor of 32.4 was obtained on the MIP monolith with the aid of macromolecular crowding agent. The PS-based imprinted monolith had imprinting even at the extremely high ratio of functional monomer to template of 1510:1. Furthermore, an off-line solid-phase extraction based on the ground MIP was conducted, and the purification recovery of ellagic acid from pomegranate-rind extract was up to 80 %. In conclusion, this approach based on macromolecular crowding is simple, and is especially valuable for those applications of MIP preparation for which a rare template is used.
关键词Monolith Molecularly Imprinted Polymer Polystyrene Ellagic Acid Macromolecular Crowding Agent
DOI10.1007/s00216-015-8902-0
收录类别SCI
WOS记录号WOS:000361396300015
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4865
专题省部共建新疆特有药用资源利用重点实验室
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Xinjiang, Peoples R China
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Sun, GY ,Zhong, DD ,Li, XJ ,et al. Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2015,407(24):7401-7412.
APA Sun, GY .,Zhong, DD .,Li, XJ .,Luo, YQ .,Ba, H .,...&Aisa, HA .(2015).Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,407(24),7401-7412.
MLA Sun, GY ,et al."Effect of minimizing amount of template by addition of macromolecular crowding agent on preparation of molecularly imprinted monolith".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 407.24(2015):7401-7412.
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