Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts-Computational and Experimental Investigations
Numonov, S (Numonov, Sodik); Edirs, S (Edirs, Salamet); Bobakulov, K (Bobakulov, Khayrulla); Qureshi, MN (Qureshi, Muhammad Nasimullah); Bozorov, K (Bozorov, Khurshed); Sharopov, F (Sharopov, Farukh); Setzer, WN (Setzer, William N.); Zhao, HQ (Zhao, Haiqing); Habasi, M (Habasi, Maidina); Sharofova, M (Sharofova, Mizhgona); Aisa, HA (Aisa, Haji Akber); Aisa, HA
2017
发表期刊MOLECULES
卷号22期号:6
摘要The root of Geranium collinum Steph is known in Tajik traditional medicine for its hepatoprotective, antioxidant, and anti-inflammatory therapeutic effects. The present study was conducted to evaluate of potential antidiabetic, antioxidant activities, total polyphenolic and flavonoid content from the different extracts (aqueous, aqueous-ethanolic) and individual compounds isolated of the root parts of G. collinum. The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0.10 mu g/mL and 0.09 mu g/mL for the enzymes protein-tyrosine phosphatase (1B PTP-1B) and alpha-glucosidase, respectively. Phytochemical investigations of the 50% aqueous-ethanolic extract of G. collinum, led to the isolation of ten pure compounds identified as 3,3 ',4,4 '-tetra-O-methylellagic acid (1), 3,3 '-di-O-methylellagic acid (2), quercetin (3), caffeic acid (4), (+)-catechin (5), (-)-epicatechin (6), (-)-epigallocatechin (7), gallic acid (8), beta-sitosterol-3-O-beta-d-glucopyranoside (9), and corilagin (10). Their structures were determined based on 1D and 2D NMR and mass spectrometric analyses. Three isolated compounds exhibited strong inhibitory activity against PTP-1B, with IC50 values below 0.9 mu g/mL, more effective than the positive control (1.46 mu g/mL). Molecular docking analysis suggests polyphenolic compounds such as corilagin, catechin and caffeic acid inhibit PTP-1B and beta sitosterol-3-O-beta-d-gluco-pyranoside inhibits alpha-glucosidase. The experimental results suggest that the biological activity of G. collinum is related to its polyphenol contents. The results are also in agreement with computational investigations. Furthermore, the potent antidiabetic activity of the 50% aqueous-ethanolic extract from G. collinum shows promise for its future application in medicine. To the best of our knowledge, we hereby report, for the first time, the antidiabetic activity of G. collinum.
关键词Geranium Collinum Steph Polyphenolic Compounds Nmr Ptp-1b Alpha-glucosidase Molecular Docking
DOI10.3390/molecules22060983
收录类别SCI
WOS记录号WOS:000404642100128
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4833
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Peoples R China
2.Acad Sci Republ Tajikistan, State Scientifically Expt & Prod Org, Dushanbe 734063, Tajikistan
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Acad Sci Uzbek, Inst Chem Plant Subst, Tashkent 100170, Uzbekistan
5.Abdul Wali Khan Univ, Dept Chem, Mardan 23200, Pakistan
6.Avicenna Tajik State Med Univ, Dept Pharmaceut Technol, Rudaki Ave 139, Dushanbe 734003, Tajikistan
7.Univ Alabama, Dept Chem, Huntsville, AL 35899 USA
8.Acad Tajik Tradit Med, Inst Avicennas Med & Pharmacol, Dushanbe 734062, Tajikistan
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Numonov, S ,Edirs, S ,Bobakulov, K ,et al. Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts-Computational and Experimental Investigations[J]. MOLECULES,2017,22(6).
APA Numonov, S .,Edirs, S .,Bobakulov, K .,Qureshi, MN .,Bozorov, K .,...&Aisa, HA.(2017).Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts-Computational and Experimental Investigations.MOLECULES,22(6).
MLA Numonov, S ,et al."Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts-Computational and Experimental Investigations".MOLECULES 22.6(2017).
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