Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity
Gao, J (Gao, Jie); Aisa, HA (Aisa, Haji A.); Aisa, HA
2017
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号80期号:6页码:1767-1775
摘要Ten new terpenoids, including five-diterpenoids (1-5); three nortriterpenoids (6-8), and two triterpenoids (9, 10), and 15 known terpenoids (11-25) were isolated from an acetone extract of Euphorbia soongarica. Sooneuphoramine (1) is the first example of a euphoractine B-type diterpenoid alkaloid, while sooneuphanones A-C (6-8) are rare nortriterpenoids from the Euphorbia genus. The isolated terpenoids were tested for their cytotoxicity and Multidrug resistance (MDR) reversal activity, 10 of which showed moderate cytotoxicity against the KB arid KBv200 cell lines, while 11 compounds exhibited PT-gp modulating potential. The triterpenoid sooneuphanone D (9) possessed a remarkable MDR reversal activity much higher than the positive control, verapamil.
DOI10.1021/acs.jnatprod.6b01099
收录类别SCI
WOS记录号WOS:000404322100008
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4819
专题省部共建新疆特有药用资源利用重点实验室
通讯作者Aisa, HA
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
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Gao, J ,Aisa, HA ,Aisa, HA. Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1767-1775.
APA Gao, J ,Aisa, HA ,&Aisa, HA.(2017).Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.JOURNAL OF NATURAL PRODUCTS,80(6),1767-1775.
MLA Gao, J ,et al."Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1767-1775.
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