XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity
Gao, J (Gao, Jie); Aisa, HA (Aisa, Haji A.); Aisa, HA
2017
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume80Issue:6Pages:1767-1775
AbstractTen new terpenoids, including five-diterpenoids (1-5); three nortriterpenoids (6-8), and two triterpenoids (9, 10), and 15 known terpenoids (11-25) were isolated from an acetone extract of Euphorbia soongarica. Sooneuphoramine (1) is the first example of a euphoractine B-type diterpenoid alkaloid, while sooneuphanones A-C (6-8) are rare nortriterpenoids from the Euphorbia genus. The isolated terpenoids were tested for their cytotoxicity and Multidrug resistance (MDR) reversal activity, 10 of which showed moderate cytotoxicity against the KB arid KBv200 cell lines, while 11 compounds exhibited PT-gp modulating potential. The triterpenoid sooneuphanone D (9) possessed a remarkable MDR reversal activity much higher than the positive control, verapamil.
DOI10.1021/acs.jnatprod.6b01099
Indexed BySCI
WOS IDWOS:000404322100008
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4819
Collection省部共建新疆特有药用资源利用重点实验室
Corresponding AuthorAisa, HA
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Chem Plant Resources Arid Reg, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
Recommended Citation
GB/T 7714
Gao, J ,Aisa, HA ,Aisa, HA. Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(6):1767-1775.
APA Gao, J ,Aisa, HA ,&Aisa, HA.(2017).Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.JOURNAL OF NATURAL PRODUCTS,80(6),1767-1775.
MLA Gao, J ,et al."Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity".JOURNAL OF NATURAL PRODUCTS 80.6(2017):1767-1775.
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