XJIPC OpenIR  > 省部共建新疆特有药用资源利用重点实验室
Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components
Edirs, S (Edirs, Salamet); Turak, A (Turak, Ablajan); Numonov, S (Numonov, Sodik); Xin, XL (Xin, Xuelei); Aisa, HA (Aisa, Haji Akber)
2017
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Volume2017Issue:5Pages:1-14
Abstract

By using extraction yield, total polyphenolic content, antidiabetic activities (PTP-1B and alpha-glycosidase), and antioxidant activity (ABTS and DPPH) as indicated markers, the extraction conditions of the prescription Kursi Wufarikun Ziyabit (KWZ) were optimized by response surface methodology (RSM). Independent variables were ethanol concentration, extraction temperature, solid-to-solvent ratio, and extraction time. The result of RSM analysis showed that the four variables investigated have a significant effect (p < 0.05) for Y-1, Y-2, Y-3, Y-4, and Y-5 with R-2 value of 0.9120, 0.9793, 0.9076, 0.9125, and 0.9709, respectively. Optimal conditions for the highest extraction yield of 39.28%, PTP-1B inhibition rate of 86.21%, alpha-glycosidase enzymes inhibition rate of 96.56%, and ABTS inhibition rate of 77.38% were derived at ethanol concentration 50.11%, extraction temperature 72.06 degrees C, solid-to-solvent ratio 1:22.73 g/mL, and extraction time 2.93 h. On the basis of total polyphenol content of 48.44% in this optimal condition, the quantitative analysis of effective part of KWZ was characterized via UPLC method, 12 main components were identified by standard compounds, and all of them have shown good regression within the test ranges and the total content of them was 11.18%.

DOI10.1155/2017/6761719
Indexed BySCI
WOS IDWOS:000401358200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.xjipc.cas.cn/handle/365002/4802
Collection省部共建新疆特有药用资源利用重点实验室
资源化学研究室
Corresponding AuthorXin, XL (Xin, Xuelei); Aisa, HA (Aisa, Haji Akber)
Affiliation1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.State Scientifically Expt & Prod Org, Acad Sci Republ Tajikistan, Dushanbe 734063, Tajikistan
Recommended Citation
GB/T 7714
Edirs, S ,Turak, A ,Numonov, S ,et al. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017,2017(5):1-14.
APA Edirs, S ,Turak, A ,Numonov, S ,Xin, XL ,&Aisa, HA .(2017).Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017(5),1-14.
MLA Edirs, S ,et al."Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017.5(2017):1-14.
Files in This Item:
File Name/Size DocType Version Access License
Optimization of Extr(6209KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Edirs, S (Edirs, Salamet)]'s Articles
[Turak, A (Turak, Ablajan)]'s Articles
[Numonov, S (Numonov, Sodik)]'s Articles
Baidu academic
Similar articles in Baidu academic
[Edirs, S (Edirs, Salamet)]'s Articles
[Turak, A (Turak, Ablajan)]'s Articles
[Numonov, S (Numonov, Sodik)]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Edirs, S (Edirs, Salamet)]'s Articles
[Turak, A (Turak, Ablajan)]'s Articles
[Numonov, S (Numonov, Sodik)]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.