Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components
Edirs, S (Edirs, Salamet); Turak, A (Turak, Ablajan); Numonov, S (Numonov, Sodik); Xin, XL (Xin, Xuelei); Aisa, HA (Aisa, Haji Akber)
2017
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
卷号2017期号:5页码:1-14
摘要

By using extraction yield, total polyphenolic content, antidiabetic activities (PTP-1B and alpha-glycosidase), and antioxidant activity (ABTS and DPPH) as indicated markers, the extraction conditions of the prescription Kursi Wufarikun Ziyabit (KWZ) were optimized by response surface methodology (RSM). Independent variables were ethanol concentration, extraction temperature, solid-to-solvent ratio, and extraction time. The result of RSM analysis showed that the four variables investigated have a significant effect (p < 0.05) for Y-1, Y-2, Y-3, Y-4, and Y-5 with R-2 value of 0.9120, 0.9793, 0.9076, 0.9125, and 0.9709, respectively. Optimal conditions for the highest extraction yield of 39.28%, PTP-1B inhibition rate of 86.21%, alpha-glycosidase enzymes inhibition rate of 96.56%, and ABTS inhibition rate of 77.38% were derived at ethanol concentration 50.11%, extraction temperature 72.06 degrees C, solid-to-solvent ratio 1:22.73 g/mL, and extraction time 2.93 h. On the basis of total polyphenol content of 48.44% in this optimal condition, the quantitative analysis of effective part of KWZ was characterized via UPLC method, 12 main components were identified by standard compounds, and all of them have shown good regression within the test ranges and the total content of them was 11.18%.

DOI10.1155/2017/6761719
收录类别SCI
WOS记录号WOS:000401358200001
引用统计
文献类型期刊论文
条目标识符http://ir.xjipc.cas.cn/handle/365002/4802
专题省部共建新疆特有药用资源利用重点实验室
资源化学研究室
通讯作者Xin, XL (Xin, Xuelei); Aisa, HA (Aisa, Haji Akber)
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.State Scientifically Expt & Prod Org, Acad Sci Republ Tajikistan, Dushanbe 734063, Tajikistan
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GB/T 7714
Edirs, S ,Turak, A ,Numonov, S ,et al. Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017,2017(5):1-14.
APA Edirs, S ,Turak, A ,Numonov, S ,Xin, XL ,&Aisa, HA .(2017).Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017(5),1-14.
MLA Edirs, S ,et al."Optimization of Extraction Process for Antidiabetic and Antioxidant Activities of Kursi Wufarikun Ziyabit Using Response Surface Methodology and Quantitative Analysis of Main Components".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017.5(2017):1-14.
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